| 系统性红斑狼疮患者血脂水平变化及与病情活动度的相关性研究 |
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| 引用本文： | 王瑞瑞,巩路.系统性红斑狼疮患者血脂水平变化及与病情活动度的相关性研究[J].天津医科大学学报,2011,17(2):246-248. |
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| 作者姓名： | 王瑞瑞 巩路 |
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| 作者单位： | 天津医科大学总医院感染免疫科,天津,300052 |
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| 摘 要： | 目的：观察系统性红斑狼疮（SLE）患者血脂变化及与病情活动的相关性。方法：选取60例SLE患者与20例正常对照者,将选取的SLE患者按照SLEDAI评分分成活动组和缓解组。同时对3组受试者血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、载脂蛋白A（ApoA1）、低密度脂蛋白（LDL）、载脂蛋白B（ApoB）及活动度评分、红细胞沉降率（ESR）、C-反应蛋白（CRP）进行检测。结果：活动组和缓解组患者与正常对照组相比,ApoA1、TC、HDL均显著下降（P〈0.05或P〈0.01）,TG、LDL明显升高（P〈0.05）,差异有统计学意义;ApoB差异无统计学意义。活动组与缓解组比较,其ApoA1显著下降（P〈0.05）,TG、LDL升高（P〈0.05）,差异有统计学意义。活动组患者Apo与脂质、蛋白代谢及活动性指标测定显示,ApoA1与HDL、前白蛋白、白蛋白呈正相关（P〈0.05或0.01）;ApoB与TG、LDL呈明显正相关（P〈0.01）;ApoA1/ApoB与HDL呈正相关（P〈0.05）,与TG、LDL、ESR呈负相关（P〈0.01或P〈0.05）。结论：SLE患者出现了HDL、ApoA1、TC显著降低,LDL、TG明显升高。表明SLE可引起脂代谢的异常,并且这种血脂水平的变化与SLE活动度密切相关。
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| 关 键 词： | 系统性红斑狼疮 血脂 载脂蛋白 炎症因子 活动度 |
Changes of serum lipids in patients with SLE and correlation between this change and the activity of SLE |
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| WANG Rui-rui,GONG Lu.Changes of serum lipids in patients with SLE and correlation between this change and the activity of SLE[J].Journal of Tianjin Medical University,2011,17(2):246-248. |
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| Authors: | WANG Rui-rui GONG Lu |
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| Institution: | WANG Rui-rui,GONG Lu(Department of Infection and Immunology,General Hospital,Tianjin Medical University,Tianjin 300052,China) |
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| Abstract: | Objective: To observe the changes of serum lipids in systemic lupus erythematosus(SLE) and the correlation between this change and the activity of SLE.Methods: 60 cases with SLE and 20 normal individuals were enrolled.The level of serum lipids,total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),low density lipoprotein(LDL),as well as active index,erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP).Results:(1) The ApoA1,TC,HDL level... |
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| Keywords: | Systemic lupus erythematosus Serum lipid Apolipoprotein Inflammatory factor Activity |
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