重组(酵母)乙型肝炎疫苗免疫后5年随访结果 |
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引用本文: | 孙超美,吴维寿,姜铭波,张国华,汪萱怡一,徐志一.重组(酵母)乙型肝炎疫苗免疫后5年随访结果[J].河南预防医学杂志,2011,22(3):170-172. |
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作者姓名: | 孙超美 吴维寿 姜铭波 张国华 汪萱怡一 徐志一 |
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作者单位: | 1. 上海市黄浦区疾病预防控制中心,免疫规划科,上海,200011 2. 复旦大学,医学分子病毒学实验室,上海,200011 3. 复旦大学,生物医学研究院,上海,200011 |
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摘 要: | 目的 探讨新生儿接种国产重组(酵母)乙型肝炎(乙肝)疫苗后的免疫效果,并与血源乙肝疫苗效果比较.方法 对1997年出生并接种重组(酵母)乙肝疫苗的新生儿隔年随访一次,采血检测乙肝病毒表面抗原(HBsAg),乙肝病毒表面抗体(抗-HBs)和乙肝病毒核心抗体(抗-HBc),1998年以后对乙肝免疫人群开展急性乙肝发病监测....
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关 键 词: | 重组(酵母)乙肝疫苗 发病监测 乙肝病毒表面抗原 随访研究 |
A Five-year Follow-up study of HBV DNA Recombinant Vaccine. |
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Institution: | SUN Chao-mei,WU Wei-shou,JING Min-bo,et al.Shanghai HuangPu District Center for Disease Control and Prevention,Shanghai 200011,China. |
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Abstract: | Objective To study immune efficacy of domestic HBV DNA recombinant vaccine given to infants and compare with plasma-derived one.Methods Every two years we tested HBsAg,anti-HBs and anti-HBc of blood taken from infants who were born in 1997 and were vaccinated with HBV DNA recombinant vaccine at their birth.After 1998,we monitored the incidence of acute hepatitis B in subjects with hepatitis B vaccine vaccinated.Result Average positive rate of HBsAg in three follow-up surveys during 5 years is about 1.50 % and dropped greatly compared with that before inoculation.Vaccine protective ratio is 83.00 %(95 %confident interval is between 76.97 %~89.02 %).The HBsAg positive rates of subjects who received different hepatitis B have no statistical difference no matter the HBsAg of their mothers is positive or negative.Acute hepatitis B is not found in subjects inoculated with HBV DNA recombinant vaccine.Conclusion HBV DNA recombinant vaccine has good short-term immunogenicity and protective efficacy which is equal to that of plasma-derived one. |
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Keywords: | HBV DNA recombinant vaccine incidence surveillance HBsAg follow-up study |
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