Polymorphisms in IL10 may alter CD4 T-cell counts in Indonesian HIV patients beginning antiretroviral therapy |
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Authors: | Deane Maria Dmello Ibnu Ariyanto Riwanti Estiasari Samuel Halstrom Jessica Gaff Silvia Lee Patricia Price |
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Affiliation: | 1. School of Biomedical Science, Curtin University, Perth, Western Australia, Australia;2. Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
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Abstract: | Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine influenced by single nucleotide polymorphisms (SNP) located in upstream regulatory regions. Here we address the effects of five SNP (rs1518111, rs3021094, rs3024491, rs1800872 and rs1800871) on CD4 T-cell counts in Indonesian HIV patients assessed before ART and over 12 months on treatment. Heterozygosity at rs1518111 or rs1800872 associated with low CD4 T-cell counts at all time points. Both alleles were carried in two haplotypes. Haplotype 21122 (present in 30% of participants) associated with low CD4 T-cell counts, whereas 21222 (in 6% of participants) did not. Hence untyped SNP(s) tagged by 21122 may depress CD4 T-cell counts. The association with heterozygosity suggests synergy with an allele from a haplotype lacking rs1518111 and/or rs1800872. |
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Keywords: | ART antiretroviral therapy IL interleukin SNP single nucleotide polymorphism Antiretroviral therapy HIV IL-10 Single nucleotide polymorphism CD4 T-cell counts Indonesia |
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