Cytokine gene polymorphisms in populations from Parana,Southern Brazil |
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| Authors: | Pâmela Guimarães Reis Josiane Bazzo de Alencar Luciana Conci Macedo Eliane Papa Ambrosio-Albuquerque Julimary Suematsu de Aquino Joana Maira Valentini Zacarias Patrícia Yumeko Tsuneto Ricardo Alberto Moliterno Ana Maria Sell Jeane Eliete Laguila Visentainer |
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| Affiliation: | 1. Post Graduation Program of Biosciences and Physiopathology, Department of Analysis Clinical and Biomedicine, Maringa State University, Parana, Brazil;2. Department of Biotechnology, Genetics, and Cell Biology, Maringa State University, Parana, Brazil;3. Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University, Parana, Brazil |
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| Abstract: | In this study, were genotyped 22 single nucleotide polymorphisms (SNPs) in 13 genes that encode the pro-inflammatory (IL-1α, IL-1β, IL-1R, IL-4Rα, IL-12, IFN-γ, TNF-α, and IL-2) and anti-inflammatory (IL-1RA, TGF-β, IL-4, IL-6 and IL-10) cytokines of 350 individuals by PCR-SSP (polymerase chain reaction – sequence specific primer). A total of 473 individuals were genotyped for IL17A and IL17F genes by PCR-RFLP (restriction fragment length polymorphism). The sample consisted of healthy and unrelated subjects from a mixed population from Parana state, in the South region of Brazil. The frequency analyses and genotype data are available in the Supplementary materials and are accessible at Allele Frequency Net Database (AFND). |
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| Keywords: | Cytokine SNPs Allele frequency Population |
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