Prostaglandin D2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production |
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| Authors: | Mojgan Masoodi Anna Nicolaou Karl Gledhill Lesley E Rhodes Desmond J Tobin Anthony J Thody |
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| Institution: | 1. Bradford School of Pharmacy, School of Life Sciences, University of Bradford, Bradford, UK;2. Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK;3. Dermatological Sciences, School of Translational Medicine, University of Manchester and Salford Royal NHS Foundation Hospital, Manchester Academic Health Sciences Centre, Manchester, UK;4. School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK |
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| Abstract: | Please cite this paper as: Prostaglandin D2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production. Experimental Dermatology 2010; 19 : 751–753. Abstract: This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX‐1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. α‐Melanocyte‐stimulating hormone, which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that α‐MSH acts independently of cAMP, possibly by regulating the activity of lipocalin‐type PGD synthase. This α‐MSH‐mediated effect may be associated with its role as an immune modulator. |
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| Keywords: | α ‐melanocyte‐stimulating hormone liquid chromatography electrospray tandem mass spectrometry melanogenesis pigment cells prostaglandin D2 |
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