P53 deletion may drive the clinical evolution and treatment response in multiple myeloma |
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Authors: | Lucía López‐Anglada Norma C. Gutiérrez Juan L. García María V. Mateos Teresa Flores Jesús F. San Miguel |
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Affiliation: | Servicio de Hematología, Hospital Universitario, Centro de Investigación del Cáncer‐IBMCC (USAL‐CSIC), Salamanca, Spain |
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Abstract: | We report a patient with multiple myeloma presenting with a paraspinal plasmacytoma with a marked dissociation between the response obtained in bone marrow (BM) infiltration and that achieved in soft tissue masses. While a complete remission was reached and maintained in BM, extramedullary plasmacytomas were refractory to every line of treatment. Genetic analysis identified the presence of t(4;14) and RB deletion in myeloma cells of both origins. However, a P53 deletion was only detected in plasma cells from extramedullary plasmacytomas. This finding suggests that P53 deletion has a role in the lack of treatment response of extramedullary plasmacytomas. |
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Keywords: | myeloma plasmacytoma cytogenetics P53 |
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