CKD-EPI equation: A suitable Glomerular Filtration Rate estimate for drug dosing in HIV-infected patients |
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Authors: | A Gagneux-Brunon E Botelho-Nevers P Delanaye F Lucht A Frésard C Cazorla C Guglielminotti C Fafin C Mariat O Moranne |
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Institution: | 1. Department of infectious and tropical diseases, university hospital of Saint-Étienne, PRES de Lyon, Lyon, France;2. Department of nephrology, dialysis, transplantation, university hospital of Liège, CHU Sart Tilman, Liège, Belgium;3. Department of nephrology, dialysis, and apheresis, hospital Caremeau, CHU de Nîmes, 30029 Nîmes cedex 9, France;4. Faculté de médecine, université Montpellier-Nîmes, 30908 Nîmes cedex 2, France;5. Department of nephrology, dialysis, transplantation, hypertension, university hospital of Saint-Étienne, PRES de Lyon, 42055 Saint-Etienne cedex 2, France;6. Groupe immunité muqueuse et agents pathogènes, université Jean-Monnet, université de Lyon, 42270 Saint-Priest-en-Jarez, France |
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Abstract: | ObjectivesTo evaluate concordance between glomerular filtration rate (GFR) estimates (Cockcroft and Gault, modification of diet in renal diseases, chronic kidney disease epidemiology study group equations) for drug dosing in HIV-infected patients.Patients and methodsWe performed a monocentric study. GFR was measured using the gold standard method (plasma clearance of iohexol) in 230 HIV-infected patients. Concordance rate was evaluated between measured GFR (mGFR) and estimated GFR (eGFR) for different GFR categories (GFR > 90 mL/min, GFR < 90 mL/min, GFR > 70 mL/min, and GFR < 70 mL/min). MDRD and CKD-EPI were used with and without indexation to body surface area (BSA).ResultsMean age was 48 ± 10 years, mean mGFR was 101 ± 26 mL/min. Concordance between mGFR and eGFR estimated with CG, CKD-EPI (indexed and not indexed to BSA), or MDRD equations (not indexed to BSA) was similar (73%, 73%, 74%, and 73% respectively) for a breakpoint value of 90 mL/min for GFR. At this value, the concordance rate between mGFR and MDRD indexed to BSA was significantly lower (65%, P < 0.05). Using 70 mL/min of GFR as the breakpoint value, all equations had similar concordance rates with mGFR (with or without indexation to BSA).ConclusionCKD-EPI equation has the same concordance with GFR and with CG when used for drug dosing. |
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Keywords: | HIV infection Glomerular filtration rate Cockcroft and Gault CKD-EPI Infection par le VIH Débit de filtration glomérulaire Cockcroft et Gault CKD-EPI |
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