Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma |
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| Authors: | Jinna Shi Shan Wang Eryang Zhao Lei Shi Xin Xu Ming Fang |
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| Institution: | 1. College of Stomatology, Harbin Medical University, Harbin, Heilongjiang;2. Department of Oral Pathology, College of Stomatology, Harbin Medical University, Harbin, Heilongjiang;3. Postgraduate Institution, Harbin Medical University, Harbin, Heilongjiang, China |
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| Abstract: | J Oral Pathol Med (2010) 39 : 548–551 Aims: To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). Methods: A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis. Results: Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type. Conclusions: Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC. |
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| Keywords: | clinicopathological features metastasis paxillin salivary adenoid cystic carcinoma |
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