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Ethical Analysis of Withdrawing Total Artificial Heart Support
Authors:Erin S. DeMartino  Sara E. Wordingham  John M. Stulak  Barry A. Boilson  Kayla R. Fuechtmann  Nausheen Singh  Daniel P. Sulmasy  Octavio E. Pajaro  Paul S. Mueller
Affiliation:1. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN;2. Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN;3. Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;4. Division of General Internal Medicine, Mayo Clinic, Rochester, MN;5. Division of Hematology and Medical Oncology, Mayo Clinic Hospital, Phoenix, AZ;6. Division of Cardiovascular and Thoracic Surgery, Mayo Clinic Hospital, Phoenix, AZ;7. Augsburg College, Minneapolis, MN;8. University of Wisconsin, Madison;9. MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL
Abstract:

Objectives

To describe the characteristics of patients who undergo withdrawal of total artificial heart support and to explore the ethical aspects of withdrawing this life-sustaining treatment.

Patients and Methods

We retrospectively reviewed the medical records of all adult recipients of a total artificial heart at Mayo Clinic from the program's inception in 2007 through June 30, 2015. Management of other life-sustaining therapies, approach to end-of-life decision making, engagement of ethics and palliative care consultation, and causes of death were analyzed.

Results

Of 47 total artificial heart recipients, 14 patients or their surrogates (30%) requested withdrawal of total artificial heart support. No request was denied by treatment teams. All 14 patients were supported with at least 1 other life-sustaining therapy. Only 1 patient was able to participate in decision making.

Conclusion

It is widely held to be ethically permissible to withdraw a life-sustaining treatment when the treatment no longer meets the patient's health care–related goals (ie, the burdens outweigh the benefits). These data suggest that some patients, surrogates, physicians, and other care providers believe that this principle extends to the withdrawal of total artificial heart support.
Keywords:AD  advance directive  AICD  automatic implantable cardioverter-defibrillator  CVA  cerebrovascular accident  ECMO  extracorporeal membrane oxygenation  FDA  US Food and Drug Administration  IABP  intra-aortic balloon pump  ICD  implantable cardioverter-defibrillator  ICU  intensive care unit  LST  life-sustaining therapy  LVEF  left ventricular ejection fraction  MOF  multiple organ failure  NPPV  noninvasive positive pressure ventilation  PM  pacemaker  RRT  renal replacement therapy  TAH  total artificial heart  VA  venoarterial  VAD  ventricular assist device  VV  venovenous
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