| 组蛋白去乙酰化酶抑制剂抗血液肿瘤的研究进展 |
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| 引用本文： | 李庆华,杨志刚.组蛋白去乙酰化酶抑制剂抗血液肿瘤的研究进展[J].医学综述,2009,15(7):1022-1024. |
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| 作者姓名： | 李庆华 杨志刚 |
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| 作者单位： | 广东医学院附属医院血液科,广东,湛江,524000 |
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| 摘 要： | 组蛋白去乙酰化酶抑制剂(HDACI)可通过调节组蛋白和非组蛋白的乙酰化水平,调控基因的表达。体内及体外实验均显示,HDACI可通过细胞周期阻滞、促进细胞分化、诱导细胞凋亡等多种生物学效应发挥其抗血液肿瘤的作用。HDACI与其他药物联合应用在抗血液肿瘤方面展现了良好的应用前景。
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| 关 键 词： | 组蛋白去乙酰化酶抑制剂 血液肿瘤 细胞凋亡 |
Research Progress of Histone Deacetylase Inhibitor in the Treatment of Hematological Malignancies |
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| LI Qing-hua,YANG Zhi-gang.Research Progress of Histone Deacetylase Inhibitor in the Treatment of Hematological Malignancies[J].Medical Recapitulate,2009,15(7):1022-1024. |
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| Authors: | LI Qing-hua YANG Zhi-gang |
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| Institution: | LI Qing-hua, YANG Zhi-gang ( Department of Hematology, the Affiliated Hospital of Guangdong Medical College ,Zhanjiang 524000, China ) |
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| Abstract: | Histone deacetylase inhibitor（HDACI） can regulate gene expression through modulate the degree of acetylation of histone and non-histone. They play an important role in resisting hematological malignancies. It was showed in vivo and vitro that they have a range of antitumor activities including induction of cell cycle arrest, stimulation of differentiation, and provocation of apoptosis. The combined chemotherapy of HDACI and other drugs display attractive prospect in the treatment of hematological malignancies. |
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| Keywords: | Historic deacetylase inhibitor Hematological malignancies Apoptosis |
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