| 人乳头瘤病毒相关头颈部鳞状细胞癌侵袭转移的分子机制 |
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| 引用本文： | 崔广学,高晓磊,梁新华. 人乳头瘤病毒相关头颈部鳞状细胞癌侵袭转移的分子机制[J]. 华西口腔医学杂志, 2018, 36(5): 544-551. DOI: 10.7518/hxkq.2018.05.015 |
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| 作者姓名： | 崔广学 高晓磊 梁新华 |
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| 作者单位： | 1. 赤峰学院附属医院口腔颌面外科,赤峰 0240002. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院口腔颌面外科教研室,成都 610041 |
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| 基金项目： | 国家自然科学基金(81361120399) |
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| 摘 要： | 人乳头瘤病毒（HPV）是头颈部鳞状细胞癌（HNSCC）的主要致病因素之一,HPV感染与HNSCC的侵袭转移存在密切关系。本文对HPV相关性头颈部鳞状细胞癌基因变异、HPV致癌蛋白E6、E7通过众多复杂细胞元件相互作用的特异性致癌机制进行了阐述,并进一步讨论了HPV阳性HNSCC侵袭转移相关的分子机制,包括非编码RNAs、肿瘤细胞的能量代谢紊乱、肿瘤细胞微环境、肿瘤干细胞、肿瘤血管生成及淋巴管生成的研究进展。
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| 关 键 词： | 人乳头瘤病毒 头颈部鳞状细胞癌 侵袭转移 |
| 收稿时间： | 2018-04-20 |
| 修稿时间： | 2018-07-24 |
Invasion and metastasis mechanism of human papillomavirus in head and neck squamous cell carcinomas |
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| Guang-xue Cui,Xiaolei Gao,Xinhua Liang. Invasion and metastasis mechanism of human papillomavirus in head and neck squamous cell carcinomas[J]. West China journal of stomatology, 2018, 36(5): 544-551. DOI: 10.7518/hxkq.2018.05.015 |
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| Authors: | Guang-xue Cui Xiaolei Gao Xinhua Liang |
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| Affiliation: | 1. Dept. of Oral and Maxillofacial Surgery, Affiliated Hospital of Chifeng University, Chifeng 024000, China2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; |
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| Abstract: | Human papillomavirus (HPV) is a major causative agent of head and neck squamous cell carcinomas (HNSCC). Over the past several decades, an increasing number of studies established the strong association of HPV with the invasion and metastasis of HNSCC. In the present study, we reviewed the gene mutations in HPV-associated HNSCC and the unique mechanism of E6- and E7-mediated carcinogenesis via interactions with an array of cellular elements. We further discussed the progress in the mechanisms of invasion and metastasis; these mechanisms include non-coding RNAs, deregulating cellular energetics, tumor microenvironment, cancer stem cells, angiogenesis, and lymphangiogenesis. |
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| Keywords: | human papillomavirus head and neck squamous cell carcinomas invasion and metastasis |
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