| 妊娠期药物动力学及口腔感染性疾病的安全用药 |
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| 引用本文： | 李宏宇,周雅川,周学东,郑黎薇.妊娠期药物动力学及口腔感染性疾病的安全用药[J].华西口腔医学杂志,2018,36(3):319-324. |
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| 作者姓名： | 李宏宇 周雅川 周学东 郑黎薇 |
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| 作者单位： | 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院儿童口腔科,成都 610041 |
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| 基金项目： | 国家自然科学基金（81470711）;国家卫生和计划生育委员会儿童口腔国家临床重点专科建设项目（0040305401313） |
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| 摘 要： | 妊娠期妇女因其所处生理阶段的特殊性,各项生理指标会有所变化,发生口腔疾病的风险急剧增加,对口腔感染性疾病不及时治疗或不合理用药可能会导致胎儿畸形甚至流产。本文对妊娠期药物动力学改变、妊娠期用药原则及治疗口腔感染性疾病常用药物进行综述,为口腔科医生对处于妊娠期口腔感染性疾病患者安全用药提供参考。
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| 关 键 词： | 妊娠 口腔保健 药物动力学 药物利用 |
| 收稿时间： | 2017-08-13 |
| 修稿时间： | 2017-12-29 |
Pharmacokinetics and drug safety of oral infectious disease during pregnancy |
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| Hongyu Li,Yachuan Zhou,Xue-dong Zhou,Liwei Zheng.Pharmacokinetics and drug safety of oral infectious disease during pregnancy[J].West China Journal of Stomatology,2018,36(3):319-324. |
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| Authors: | Hongyu Li Yachuan Zhou Xue-dong Zhou Liwei Zheng |
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| Institution: | State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China |
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| Abstract: | Pregnancy is a time of particular vulnerability in terms of physiologic changes resulting in higher risk of oral infectious diseases. There is emerging evidence showing that irrational dental treatment and drug therapy are associated with adverse pregnancy outcomes, including infant malformation or spontaneous abortion. This article reviews the pharmacokinetics of medications in pregnant women and the fetus and introduces a guideline for drug therapy and common dental drugs used during pregnancy. |
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| Keywords: | pregnancy oral health pharmacokinetics medication |
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