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双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎1例
引用本文:孙照薇,李志勇,余丹,朱洁颖,张伊殿,朱鑫美. 双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎1例[J]. 华西口腔医学杂志, 2019, 37(2): 224-228. DOI: 10.7518/hxkq.2019.02.017
作者姓名:孙照薇  李志勇  余丹  朱洁颖  张伊殿  朱鑫美
作者单位:浙江大学医学院附属口腔医院口腔颌面外科;浙江大学医学院附属第一医院口腔颌面外科,杭州,310006
摘    要:双膦酸盐类药物可以抑制破骨细胞功能,使颌骨骨密度升高,血流减少,发生骨坏死。双膦酸盐类药物相关性骨坏死多发于颌骨。本文报道1例双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎,并结合文献讨论双膦酸盐药物性颌骨坏死的发病机制、治疗与预防等。

关 键 词:双膦酸盐  颌骨坏死  舟状骨骨髓炎  唑来膦酸
收稿时间:2018-06-10
修稿时间:2018-11-08

Bisphosphonate-related osteonecrosis of the jaw complicated with wrist scaphoid osteomyelitis: a case report
Zhaowei Sun,Zhiyong Li,Dan Yu,Jieying Zhu,Yidian Zhang,Xinmei Zhu. Bisphosphonate-related osteonecrosis of the jaw complicated with wrist scaphoid osteomyelitis: a case report[J]. West China journal of stomatology, 2019, 37(2): 224-228. DOI: 10.7518/hxkq.2019.02.017
Authors:Zhaowei Sun  Zhiyong Li  Dan Yu  Jieying Zhu  Yidian Zhang  Xinmei Zhu
Affiliation:1.Dept. of Oral and Maxillofacial Surgery, Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China2.Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
Abstract:Bisphosphonates can directly inhibit osteoclasts, which may lead to increased bone density, reduced blood flow, and osteonecrosis of the jaw. Bisphosphonate-related osteonecrosis is usually observed in the jaw bone. In this article, we report a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) complicated with wrist scaphoid osteo-myelitis. Furthermore, we introduce the pathogenesis, treatment, and prevention of BRONJ.
Keywords:bisphosphonate  osteonecrosis of the jaw  scaphoid osteomyelitis  zoledronic acid  
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