超声诊断弥漫性胰腺脂肪浸润的临床意义

目的探讨超声诊断弥漫性胰腺脂肪浸润的临床意义，分析弥漫性脂肪浸润与血脂、血糖浓度的关系。 方法选取2016年6月~11月在扬州大学附属医院进行健康体检的64 155位受检者，超声诊断为弥漫性胰腺脂肪浸润的共1030例，随机选取同期无胰腺脂肪浸润的4229例受检者作为无胰腺脂肪浸润组，整理所选受检者的体检报告资料，通过χ²检验分析弥漫性胰腺脂肪浸润组与无胰腺脂肪浸润组间高血脂、高血糖发生率的差异，并采用独立样本t检验探讨弥漫性胰腺脂肪浸润与血脂、血糖浓度的关系。 结果弥漫性胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率分别为23.7%、14.1%及62.1%，无胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率分别为11.1%、10.2%及34.5%，弥漫性胰腺脂肪浸润组空腹高血糖、高胆固醇、高甘油三酯的发生率显著高于无胰腺脂肪浸润组，差异均有统计学意义（χ²=112.74、13.00、259.36，P均<0.001）。弥漫性胰腺脂肪浸润组空腹血糖、胆固醇、甘油三酯的平均浓度分别为（5.86±1.91）mmol/L、（4.72±0.94）mmol/L及（2.45±2.03）mmol/L；无胰腺脂肪浸润组空腹血糖、胆固醇、甘油三酯的平均浓度分别为（5.30±1.31）mmol/L、（4.54±0.90）mmol/L及（1.74±1.80）mmol/L，弥漫性胰腺脂肪浸润组空腹血糖、胆固醇及甘油三酯浓度显著高于无胰腺脂肪浸润组，差异均有统计学意义（t=11.12、5.48、11.74，P均<0.001）。 结论超声诊断弥漫性胰腺脂肪浸润对于提示无症状的高血脂、高血糖有重要的临床价值，可为临床早期进行干预治疗提供依据。

Ultrasound diagnosis of diffuse pancreatic fatty infiltration and its relationship with blood lipids and blood glucose

ObjectiveTo investigate the relationship between diffuse pancreatic fatty infiltration with blood lipids and blood glucose. MethodsFrom June 2016 to November 2016, 64,155 subjects underwent physical examination in the affiliated hospital of Yangzhou University. There were 1030 cases of diffuse pancreatic fatty infiltration diagnosed by ultrasound. 4229 cases without pancreatic adipose infiltrate at the same time were randomly selected as a non-invasion group. The physical examination report data of the selected subjects were analyzed, and the differences in the incidence of hyperlipidemia and hyperglycemia between the diffuse pancreatic fat infiltration group and the non-pancreatic fat infiltration group were compared by χ² test. Independent sample t test was used to explore the relationship between diffuse pancreatic fat infiltration and blood lipids and blood glucose. ResultsThe incidence of fasting hyperglycemia, high cholesterol and high triglycerides was 23.7%, 14.1%, and 62.1% in diffuse pancreatic fat infiltration group, respectively. The incidence of fasting hyperglycemia, high cholesterol and high triglycerides in non-pancreatic fat infiltration group was 11.1%, 10.2%, and 34.5%, respectively. The incidence of fasting hyperglycemia, high cholesterol and high triglycerides in the diffuse pancreatic fat infiltration group was significantly higher than that in the non-pancreatic fat infiltration group (The value of χ² were 112.74, 13.00 and 259.36, respectively, P<0.001). The average concentrations of fasting plasma glucose, cholesterol, and triglycerides in the diffuse pancreatic fat infiltration group were (5.86±1.91) mmol/L, (4.72±0.94) mmol/L and (2.45±2.03) mmol/L, respectively. The average concentrations of blood glucose, cholesterol and triglycerides in non-pancreatic fat infiltration group were (5.30±1.31) mmol/L, (4.54±0.90) mmol/L and (1.74±1.80) mmol/L, respectively. The average concentrations of fasting blood glucose, high cholesterol and high triglycerides in diffuse fatty pancreatic infiltration were significantly higher than those in the non-pancreatic fat infiltration group (P<0.001). ConclusionsDiffuse pancreatic fat infiltration is significantly associated with fasting blood glucose, cholesterol and triglyceride concentrations. Ultrasound diagnosis of diffuse pancreatic fat infiltration has important clinical value for asymptomatic hyperlipidemia and hyperglycemia, and can be used for early clinical intervention and treatment.