Glycation of lipoproteins and accelerated atherosclerosis in non-insulin-dependent diabetes mellitus |
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Authors: | A Yegin T özben H Yegin |
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Institution: | (1) Present address: Department of Biochemistry, Mediterranean University School of Medicine Hospital, Akdeniz University, TR-07070 Antalya, Turkey;(2) Department of Cardiology, Mediterranean University School of Medicine Hospital, Akdeniz University, TR-07070 Antalya, Turkey |
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Abstract: | Summary We used a new and remarkably simple method to examine the extent of in vivo lipoprotein glycation in type II diabetic patients
with atherosclerosis and diabetic patients with no complications. Serum glycated lipoprotein levels were determined by agarose
gel film electrophoresis in 48 non-diabetic control subjects and 39 diabetic patients, of whom 26 had no complications and
13 had atherosclerotic heart disease. Fasting serum glucose, glycohemoglobin and serum fructosamine concentrations (indicators
of glycemia) and total cholesterol, triglyceride, low-density lipoprotein-, very low-density lipoprotein-and high-density
lipoprotein-cholesterol concentrations and the low-density lipoprotein/high-density lipoprotein ratio (serum lipid profile)
were also detewrmined in the control and diabetic subjects. Glycated low-density lipoprotein and very low-density lipoprotein
concentrations were significantly increased in diabetic patients compared with controls; but only glycated very low-density
lipoprotein was significantly increased in atherosclerotic patients compared with diabetics without complications. The lipid
profile parameters were not significantly increased in patients compared with controls. In diabetics, especially those with
poorly controlled hyperglycemia and atherosclerosis, glycation of lipoprotein fractions might be more important than serum
lipid and lipoprotein abnormalities. The significant correlation between atherosclerosis and glycated very low-density lipoprotein,
suggests that very low-density lipoprotein glycation could be responsible for the development of atherosclerosis in diabetes. |
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Keywords: | Lipoprotein glycation Accelerated atherosclerosis Non-insulin-dependent diabetes mellitus |
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