细胞信号转导通路MEK在宫颈癌前病变和宫颈癌的表达及意义

目的：探讨宫颈癌前病变及宫颈癌组织中丝裂原激活细胞外信号调节激酶（mitogen-activated extracellular signal-regulated kinase，MEK）细胞信号转导通路表达的意义。方法：选择并收集2013年1月—2014年4月在天津市第一中心医院妇科诊治、临床病理资料完整的宫颈病变患者共92例，根据宫颈病变程度将患者分为正常组（30例）、高级别宫颈上皮内瘤样变（CIN）组（30例）和宫颈癌组（32例）。用免疫组织化学SP法检测MEK在不同组织中的表达。结果：MEK在正常组、高级别CIN组和宫颈癌组中阳性表达率分别为20.0%、56.7%和68.8%，其中宫颈癌组MEK阳性表达率最高，分别高于高级别CIN组及正常组，差异有统计学意义（P＜0.05）。高级别CIN组MEK的阳性表达率高于正常组（P=0.003）。MEK阳性表达率与患者年龄、宫颈癌病理类型、肿瘤组织分化程度、肿瘤大小及宫颈癌临床分期等因素无关（P＞0.05）。结论：MEK转导通路可能在宫颈癌及癌前病变的发生发展中有一定的作用。

The Expression and Its Significance of Cell Signal Transduction Pathways MEK in Cervical Precancerous Lesions and Cervical Cancer

Objective:To explore the expressssion of mitogen-activated extracellular signal-regulated kinase (MEK) signaling pathways in cervical precancerous lesions and cervical cancer. Methods:A total of 92 patients with cervical lesions were collected between January 2013 and April 2014 in the department of gynecology of Tianjin First Central Hospital. According to the degree of cervical lesions, the patients were divided into three groups: normal group (30 cases), high level cervical intraepithelial neoplasia (CIN) group (30 cases), cervical cancer group (32 cases). Using immunohistochemical SP method to detect the MEK expression in different tissues. Results:In normal group, high level CIN group and cervical cancer group, the positive rates of MEK were 20.0%,56.7%,68.8%respectively. MEK positive expression rate is highest in the cervical cancer group, higher than that of the high level CIN group and normal group(P<0.05). The difference between the normal group and the high level CIN group was the statistical significant(P=0.003). MEK positive expression rate had no correlated with patients' age, cervical cancer pathological type, degree of tumor differentiation, tumor size and clinical stage (P>0.05). Conclusions:MEK pathway may play a certain role in cervical cancer and precancerous lesion development.