胆汁淤积性肝纤维化中信号通路的研究进展

肝纤维化在慢性肝脏损伤中属于损伤-修复应答的模型,并且肝星状细胞为产生肝脏细胞外基质的主要细胞,在肝纤维化的进程中发挥决定性作用,其活化、增殖是肝纤维化发生的中心环节.胆汁淤积是指在肝细胞水平或胆管水平发生的胆汁生成、分泌或流动障碍,存在于肝细胞与胆管细胞膜上的众多蛋白质是胆汁形成与分泌的重要转运体.近年来对肝纤维化的信号转导通路取得了很多进展,有关胆汁淤积性肝纤维化的研究也日益完善,随着对这些转运体的认识以及对影响胆汁酸盐合成、转运的复杂信号网络系统的深入了解,该文主要就TGF-β/Smad、MAPK、JAK/STAT、NF-κB、Wnt等信号通路在胆汁淤积性肝纤维化的研究进展进行探讨.

Progress of signal transduction pathway in cholestatic hepatic fibrosis

Hepatic fibrosis is a damage and repair response model in chronic liver damage process.Hepatic stellate cells (HSC) play a determinant role as the main cells to produce liver extracellular matrix in the process of liver fibrosis,the activation and proliferation of HSC is the key link in liver fibrosis.Cholestasis is refers to the disorder in generation,secretion and flow of bile at the hepatocyte or bile duct level.The proteins exist in membranes of the liver cells and bile duct cells are important transporters to produce and secrete bile.In recent years,much progress have been made in signal transduction pathways of liver fibrosis,and the relevant research of cholestatic liver fibrosis is increasingly improvement,with the in-depth understanding of these transporters,complex signal network system of bile salt's synthesis and transport,this paper mainly through TGF-β/Smad,MAPK,JAK/STAT,NF-κ B and Wnt signal pathways to investigate the progress of signal transduction mechanism of cholestatic hepatic fibrosis.