2014-2016年北京市严重急性呼吸道感染病例监测研究

目的 分析2014年8月-2016年7月北京市严重急性呼吸道感染(SARI)病例监测中监测到的SARI病例的流行病学、病原学和临床特征.方法 在北京市11家哨点医院开展SARI监测,收集病例的流行病学与临床信息,采集并检测病例的呼吸道标本,分析2014年8月至2016年7月SARI病例的流行病学、病原学和临床特征.结果 11家哨点医院共监测到6144例SARI病例,收集5125名病例的临床信息,采集5885名病例的呼吸道标本.SARI病例占入院病例数的11.1％.SARI病例中流感的阳性率为13.5％.5125例SARI患者中,男性占58.3％,以＜5岁(34.1％)和≥60岁(31.6％)者为主,基础病的患病率为31.8％,平均住院时间为7天.流感患者中肺部基础病者的比例高于非流感病例(19.0％ vs 14.1％,P＜0.001).流感病例的平均住院时间短于非流感病例(7dvs 8d,P=0.001).流感与非流感病例的ICU治疗率和死亡率的差异无统计学意义.结论 开展SARI监测对于了解流感在住院病例中的分布特征,以及流感导致的重症病例的临床特征等方面具有重要的意义.

Sentinel surveillance for influenza among severe acute respiratory infection in Beijing, 2014-2016

Objective To characterize the epidemiology,virology,and clinical features of influenza in Beijing's severe acute respiratory infection (SARI) sentinel surveillance system,August 2014-July 2016.Methods Epidemiological and clinical information was collected from inpatients who met the definition of SARI from 11 sentinel hospitals in Beijing.Their respiratory tract specimens were collected for influenza RNA detection.SARI cases were characterized in epidemiology,virology,and clinical features.Results A total of 6144 SARI cases were found from 11 sentinel hospitals.Among them 5125 were investigated,and 5885 were sampled.SARI cases accounted for 11.0％ of all inpatients in surveillance wards.Around 13.5％ of SARI cases were influenza virus positive.Among all investigated SARI cases,males accounted for 58.3％.Cases aged ＜5 and ≥60 years-old constituted the largest part,at 34.1％ and 31.6％,respectively.SARI cases with underlying conditions accounted for 31.8％.The median interval of hospitalization for SARI cases was 7 days.Compared with influenza-negative cases,influenza-positive SARI cases were more likely to have underlying lung diseases (19.0％ vs 14.1％,P ＜ 0.001),a shorter duration of hospitalization (7d vs 8d,P =0.001).The proportion of ICU admission and mortality had no statistical differences between influenza-negative and influenza-positive cases.Conclusions SARI surveillance contributed to the understanding of the epidemiology,virology and clinical feature of SARI cases in Beijing.