血清微量元素水平与早期自然流产的相关性

目的：探讨微量元素与早期自然流产相关性，为临床上防治早期自然流产提供理论依据和实践指导。方法收集2015年4月至2016年5月在西安交通大学第一附属医院就诊的早期妊娠妇女62名及未孕育龄妇女63名，分为自然流产组（31名）、正常早孕组（31名）、正常未孕组（31名）和有自然流产史未孕组（32名），采用原子吸收法检测4组妇女外周血铜、锌、钙、镁、铁元素的含量并进行比较。结果4组妇女血清中钙及铁水平存在明显差异（F值分别为2．73、4．76，均P＜0．05）；进一步组间两两比较发现，正常早孕组血清中钙的水平明显高于早期自然流产组（P＜0．05），且血清铁水平明显高于早期自然流产组和有流产史的未孕妇女组（均P＜0．05），正常未孕组妇女血清铁水平则明显高于有流产史的未孕组妇女（P＜0．05），4组妇女血清中铜、锌和镁水平比较无明显差异（ F值分别为0．16、1．23、1．30，均P＞0．05）。结论血清钙及铁水平低与早期妊娠自然流产有一定的相关性，妇女在妊娠前和妊娠期应注意保持营养平衡。

Correlation between serum levels of trace elements and early spontaneous miscarriage

Objective To study the correlation between levels of trace elements and early spontaneous miscarriage, so as to provide theoretical and practical guidance for prevention of spontaneous miscarriage.Methods Sixty-two women at early pregnancy and 63 non-pregnant childbearing women visiting the First Affiliated Hospital in Xi ’ an Jiaotong University were selected, from April 2015 to May 2016, and they were divided into spontaneous miscarriage group (31cases), normal early pregnant group (31 cases), normal non-pregnant group (31 cases) and non-pregnant group with abortion history (32 cases).Serum copper, zinc, iron, magnesium and calcium were measured and compared among 4 groups.Results There were significant differences in mean serum calcium and iron levels among four groups (F value was 2.73 and 4.76,respectively,both P<0.05).Group comparison showed that the mean serum calcium and iron levels in normal early pregnant group were significantly higher than that in spontaneous miscarriage group (P<0.05), and that the iron level was higher than that in spontaneous miscarriage group and non-pregnant group with abortion history (both P<0.05).The iron level in normal non-pregnant group was significantly higher than that in non-pregnant group with abortion history (P<0.05).The mean serum copper, zinc and magnesium levels were not significantly different among four groups (F value was 0.16,1.23 and 1.30,respectively,all P>0.05).Conclusion Low maternal serum iron and calcium concentration may be associated with early miscarriage.Proper, adequate and balanced micronutrient before and during pregnancy is needed to prevent miscarriage.