持续正压通气治疗阻塞性睡眠呼吸暂停低通气综合征依从性问题研究

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是睡眠时上气道塌陷阻塞引起呼吸暂停及通气不足,伴有打鼾、睡眠结构紊乱、血氧饱和度频繁下降及白天嗜睡等病症.目前无创正压通气作为成人OSAHS患者的首选治疗,方法以持续正压通气(CPAP)最为常用,但依从性差仍是目前不容忽视的问题.相关分析研究显示CPAP治疗OSAHS患者依从性为30％～60％,影响了患者生活质量,同时增加合并心脑血管等全身疾病的风险.进一步探究CPAP依从性差的影响因素及积极采歇干预措施有助于提高CPAP的治疗效果及改善OSAHS患者的生活质量.

Research on the compliance for OSAHS patients treated by CPAP

Obstructive sleep apneahypopnea syndrome (OSAHS) refers to the apnea and hypoventilation induced by the repeated collapse and obstruction of the upper airway during sleep.OSAHS causes frequent oxygen desaturation and is accompanied by symptoms such as snoring,sleep structural disturbance,and daytime sleepiness.Positive airway pressure therapy is the first-line treatment for OSAHS,continuous positive airway pressure (CPAP) is most commonly used,however,some patients find it difficult to tolerate to CPAP therapy for varied reasons.Current study shows that poor adherence (30％-60％) is a significant limiting factor in treating OSAHS,which reduces the overall effectiveness of the treatment and leaves many OSAHS patients at heightened risk for cardiovascular and co-morbid conditions,as well as impaired quality of life.It is imperative to explore the factors of poor compliance of CPAP,and to promote CPAP adherence in order to improve health and functional outcomes in all patients with OSAHS.