人巨细胞病毒对药疹病情发生发展的影响

目的 探究人巨细胞病毒对药疹病情发生发展的影响.方法 选取2012年9月-2014年6月在我院就诊的50例药疹患者作为观察组,同期选取50例体检健康者作为对照组,采用Taqman实时荧光定量PCR检测外周血单一核细胞中巨细胞病毒(CMV) DNA阳性率及载量,用酶联免疫吸附试验(ELISA)检测血清中CMV IgM阳性率,对结果进行对比分析.结果 观察组中出现32例CMV DNA阳性患者,阳性率为64％.对照组中出现13例CMV DNA阳性患者,阳性率为26％,两者相比.观察组阳性率显著高于对照组,其差异具有统计学意义(P＜0.05);观察组中CMV DNA载量为28188.824±19525.632拷贝,对照组中CMV DNA载量为3018.9532±1 761.958拷贝,观察组显与对照组比较差异显著,具有统计学意义(P＜0.05);观察组中出现11例CMV IgM阳性患者,阳性率为22％,对照组中出现5例阳性患者,阳性率为10％,两者相比.观察组CMV IgM阳性率显著高于对照组,差异具有统计学意义(P＜0.05).结论 药疹患者中存在CMV感染,其在药疹的发生和发展过程中可能起到一定的促进作用,是药疹发病的因素之一.

Effect of human cytomegalovirus on the occurrence and development of drug rash

Objective To explore the effect of human cytomegalovirus on occurrence and development of disease drug rash.Methods 50 cases of patients with drug rash who were treated in our hospital from September 2012 to June 2014 were selected as the observation group, 50 cases healthy subjects were selected as the control group in the same period.Cytomegalovirus (CMV) DNA in peripheral blood mononuclear cells were detected by real-time PCR and CMV IgM was detected by enzyme-linked immunosorbent assay (ELISA).Results The positive rate of CMV DNA in the observation group was 64％ (32/50) and the positive rate of CMV DNA in the control group was 26％ (13/50).The positive rate of the observation group was significantly higher than that of the control group (P ＜ 0.05).CMV DNA load in the observation group was (28188.824 + 19525.632) copies and (3018.9532 + 1761.958) copies in the control group.The difference was statistically significant (P ＜ 0.05).The positive rate of CMV IgM was 22％ in the observation group and 10％ in the control group.CMV IgM positive rate of the observation group was significantly higher than that of the control group (P ＜ 0.05).Conclusions Drug rash patients infected with CMV may play a certain role in the occurrence and development of drug eruption.