儿童病毒感染与川崎病发病及冠状动脉病变的相关性

目的：探究病毒感染与川崎病（ KD）发病及冠状动脉病变的相关性。方法选取KD儿童105例为KD组，同期选取发热性疾病但非KD患儿210例为非KD组。对两组患儿的病毒感染情况进行比较，并行超声心动图检查，比较两组儿童冠状动脉病变情况。结果两组患儿中病毒感染232例，其中，KD组感染96例，占91．43％，非KD组感染136例，占64．76％。两组EB病毒感染率比较，KD组患儿明显高于非KD组患儿，差异具有统计学意义（χ2＝32．874，P＜0．001）；呼吸道合胞病毒、副流感病毒、流感病毒、腺病毒、单纯疱疹病毒、冠状病毒感染率两组比较，差异均无统计学差异（均P＞0．05）。分别将KD组和非KD组分为感染组与未感染组，其中KD组中感染组患儿冠状动脉损伤率最高，为46．55％（43／96），显著高于KD组的未感染组（11．11％），差异均具有统计学意义（确切概率法得出P＝0．04），亦高于非KD组的感染组（7．59％）和未感染组（8．22％），差异均具有统计学意义（χ2值分别为42．45、27．41，均P＜0．001）；而KD组中未感染组（11．11％）、非KD组的感染组（7．95％）和未感染组（8．11％）比较差异无统计学意义（P＞0．05）。结论患儿病毒感染与KD发病有关，且病毒感染的KD患儿更易发生冠状动脉病变。

Relationship between virus infection in children with Kawasaki disease and coronary artery disease

Objective To investigate the relationship between virus infection in children with Kawasaki disease ( KD) and coronary artery disease.Methods Totally 105 cases of children with KD were selected in KD group , and 210 children with febrile disease but without KD were chosen in non-KD group.The status of virus infection and coronary artery injury were compared between two groups by ultrasonic cardiogram examination.Results There were 232 cases with virus infection, including 96 cases (91.43%) in KD group and 136 cases (64.76%) in non-KD group.EB virus infection rate in KD group was significantly higher than in non-KD group, and the difference was statistically significant (χ2 =32.874,P<0.001).The infection rate of RS virus, parainfluenza virus, influenza virus, adenovirus, fever blisters virus and coronavirus was not significantly different between two groups (all P>0.05).Both KD group and non-KD group were divided into infection group and non-infection group.The coronary artery injury rate was highest in infection group of KD group (46.55%, 43/96), which was higher than that in non-infection group (11.11%), and the difference was statistically significant (P=0.04).It was also higher than that in infection group of non-KD group (7.59%) and non-infection group (8.22%), and the difference was significant (χ2 value was 42.45 and 27.41, respectively, both P<0.001).However, the difference was not statistically significant among non-infection group of KD group (11.11%), infection group (7.85%) and non-infection group (8.11%) of non-KD group (P>0.05). Conclusion KD may be correlated with virus infection , and infected children are more likely to suffer coronary artery injury .