转化生长因子β/骨形成蛋白通路与肺动脉高压遗传学机制的研究进展

肺动脉高压由多种心、肺疾病所致,以动脉压力进行性升高、肺血管阻力逐渐增加为特征,最终导致右心衰竭和死亡,其发病机制至今尚未完全阐明.近期有研究发现,转化生长因子β/骨形成蛋白通路对肺动脉高压的发生发展可产生重要影响.针对转化生长因子β/骨形成蛋白通路的研究为肺动脉高压的防治提供了新的理论依据.该文就转化生长因子β/骨形成蛋白通路与肺动脉高压遗传学机制作一综述.

Progress of transforming growth factor beta/bone morphogenetic protein pathway and genetic mechanisms of pulmonary arterial hypertension

Pulmonary arterial hypertension is the result of a variety of heart,lung disease and finally leads to right heart failure and death.Pulmonary arterial hypertension is characterized by the progressive increasing of artery pressure and the gradually increasing of pulmonary vascular resistance,and its pathogenesis has not been fully elucidated.Recent studies have found that transforming growth factor beta/bone morphogenetic protein pathway plays an important role in pulmonary arterial hypertension.The research about transforming growth factor betal bone morphagenetic protein pathway provides a new theoretical basis for the prevention and treatment of pulmonary arterial hypertension.This review focuses on progress of transforming growth factor beta/bone morphogenetic protein pathway and genetic mechanisms of pulmonary arterial hypertension.