维生素D与癫疒间的相关性研究进展

维生素D除参与调节体内钙磷代谢外，其缺乏与全身和神经系统的多种疾病的发病密切相关，如多发性硬化、阿尔茨海默症、帕金森病和脑血管疾病等。近年来研究发现维生素D可能在癫疒间的发病机制中起着重要作用，并可能具有一定的抗惊厥作用。该文对维生素D在癫疒间中的作用，血清维生素D水平及其受体基因的多态性与癫疒间的关系进行了综述，也总结了抗癫疒间药和维生素D之间的相互作用。

Updates on the relationship between vitamin D and epilepsy

Vitamin D adjusts the body′s absorption and utilization of calciumand phosphorus. Vitamin D deficiency is closely related to incidence of many disease. Several disorders,both systemic and those of the nerv-ous system,have been linked with vitamin D deficiency. Neurological disorders with a vitamin D link include but are not limited to multiple sclerosis,Alzheimer and Parkinson disease,as well as cerebrovascular disorders. In re-cent years,studies have found that the vitamin D may play a critical role in the pathogenesis of epilepsy and pos-sess certain anticonvulsant effects. This article summarized the role of vitamin D in the nervous system and epi-lepsy,the level of serum vitamin D and the correlation of the polymorphism of its receptor genes with epilepsy. The review also summarizes the interaction between antiepileptic drugs and vitamin D.