S100A8、S100A9在卵巢癌中的研究进展

由位于表皮分化簇基因编码的S100蛋白属小分子钙结合蛋白,是正常表皮分化所必需的,表达具有种属特异性,只在脊椎动物中表达。S100A8、S100A9为S100蛋白家族成员,两者在体内可形成二聚体或异二聚体发挥作用,参与多种细胞功能调节。S100A8和S100A9可诱导白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)、IL-17、IL-6等多种炎症因子的表达,与炎症的发生、发展密切相关。另外,S100A8和S100A9可通过Wnt信号通路、晚期糖基化终产物受体(RAGE)和Akt1/Smad5-ID3-p21信号通路,影响细胞的增殖、凋亡和侵袭迁移能力,在肿瘤的发生、发展中发挥重要作用,并通过活化细胞外调节蛋白1/2(ERK1/2)和p70核糖体蛋白S6激酶(p70S6K),在肿瘤耐药中也发挥着不容忽视的作用。对S100A8、S100A9及其在卵巢癌中的研究进展进行综述。

Research Progress of S100A8 and S100A9 Proteins in Ovarian Neoplasms

S100 proteins are small calcium binding proteins, which encoded by genes located in the epidermal differentiation complex, and they are expressed exclusively in vertebrates and are indispensable for normal epidermal differentiation. S100A8 and S100A9 proteins belong to S100 proteins family, which act as homodimers and heterodimers in regulating many cellular functions. S100A8 and S100A9 were associated with inflammatory by inducing the expression of cytokines, such as IL-1β, TNF-α, IL-17, IL-6. Meanwhile, many researchers discovered both of them are connected with development of tumors by acting with Wnt signaling pathway, RAGE and Akt1/Smad5-ID 3-p21 signaling to impact on proliferation, apoptosis and invasiveness. Besides, S100A8 and S100A9 act as regulator of tumor drug resistance by activating ERK1/2 and p70S6K. Herein, we review the progress of S100A8 and S100A9 proteins in ovarian neoplasms.