Computed tomography enterography and 18F-FDG PET/CT features of primary signet ring cell carcinoma of the small bowel in a patient with Crohn's disease |
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| Authors: | Francesco Paparo Arnoldo Piccardo Matteo Clavarezza Riccardo Piccazzo Lorenzo Bacigalupo Luca Cevasco Eugenio Marinaro Gian Andrea Rollandi |
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| Institution: | 1. Department of Radiology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy;2. Unit of Nuclear Medicine, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy;3. Unit of Medical Oncology, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy;4. School of Radiology, University of Genoa, Via L.B. Alberti 4, 16132 Genoa, Italy;5. Histopathology Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy |
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| Abstract: | We report a case of a primary signet ring cell carcinoma (PSRCC) of the small bowel in a patient with long-standing Crohn's disease, describing computed tomography (CT)-enterography (CTE) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT features of this rare tumor. CTE demonstrated submucosal thickening of a long ileal segment with preserved mural stratification. PET/CT examination showed increased 18F-FDG uptake in the affected ileal loop, hypermetabolic abdominal and mediastinal lymphadenopathies, and multiple hypermetabolic bone lesions. Iliac crest osteo-medullary biopsy revealed bone marrow infiltration by “signet ring” cells with intestinal differentiation. Double-balloon enteroscopy was used to obtain biopsies that confirmed the ileal origin of the PSRCC. |
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