Emotion recognition impairment is present early and is stable throughout the course of schizophrenia |
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| Authors: | Anna Comparelli Valentina Corigliano Antonella De Carolis Iginia Mancinelli Giada Trovini Giorgia Ottavi Julia Dehning Roberto Tatarelli Roberto Brugnoli Paolo Girardi |
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| Affiliation: | 1. NESMOS Department (Neurosciences, Mental Health and Sense Organs) Unit of Psychiatry, Sant''Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Italy;2. NESMOS Department (Neurosciences, Mental Health and Sense Organs) Unit of Psychological Medicine, Sant''Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Italy;1. School of Psychology, University of Sydney, NSW, Australia;2. The Brain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute, University of Sydney, NSW, Australia;3. ARC Centre of Excellence in Cognition and Its Disorders, Sydney, NSW, Australia;4. Walker Unit, Concord Centre for Mental Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia;5. Department of Psychological Medicine, The Children''s Hospital, Westmead, NSW, Australia;6. Discipline of Psychiatry, Sydney Medical School, University of Sydney, Sydney, Australia;7. Psychiatry and Behavioral Sciences, Stanford University, CA, USA;1. Departments of Psychology and Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 1N4;2. Minneapolis Veteran''s Affairs Healthcare System and Departments of Psychiatry and Psychology, University of Minnesota, Canada;1. Castle Peak Hospital, Hong Kong Special Administration Region, China;2. Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;3. University of Chinese Academy of Sciences, Beijing, China |
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| Abstract: | Individuals with schizophrenia experience problems in the perception of emotion throughout the course of the disorder. Few studies have addressed the progression of the deficit over time. The present investigation explores face emotion recognition (FER) performance throughout the course of schizophrenia. The aim of the study was to test the hypotheses that: 1) FER impairment was present in ultra high-risk (putatively prodromal) individuals, and that 2) impairment was stable across the course of the illness. Forty-three individuals with a putative prodromal syndrome, 50 patients with first episode of schizophrenia, 44 patients with multi-episode schizophrenia and 86 unaffected healthy control subjects were assessed to examine emotion recognition ability. ANCOVA analysis adjusted for possible confounder factors and subsequent planned contrasts with healthy controls was undertaken. The results revealed deficits in recognition of sadness and disgust in prodromal individuals, and of all negative emotions in both first-episode and multi-episode patients. Furthermore, there were no significant differences between clinical groups. Within the framework of the neurodevelopmental model of schizophrenia, our results suggest the presence of emotional recognition impairment before the onset of full-blown psychosis. Moreover, the deficit remains stable over the course of illness, fitting the pattern of a vulnerability indicator in contrast to an indicator of chronicity or severity. |
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