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Growth hormone combined with child-specific motor training improves motor development in infants with Prader-Willi syndrome: A randomized controlled trial |
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| Authors: | Linda Reus Ben J Pelzer Barto J Otten Elbrich PC Siemensma Janielle AAEM van Alfen-van der Velden Dederieke AM Festen Anita CS Hokken-Koelega Maria WG Nijhuis-van der Sanden |
| Institution: | 1. Radboud University Nijmegen Medical Centre, Department of Rehabilitation, Pediatric Physical Therapy, 818, PO Box 9101, 6500 HB Nijmegen, The Netherlands;2. Radboud University Medical Centre, Scientific Institute for Quality of Healthcare, 114, PO Box 9101, 6500 HB Nijmegen, The Netherlands;3. Radboud University Nijmegen, Faculty of Social Sciences, PO Box 9104, 6500 HE Nijmegen, The Netherlands;4. Radboud University Nijmegen Medical Centre, Department of Pediatric Endocrinology, 804, PO Box 9101, 6500 HB Nijmegen, The Netherlands;5. Dutch Growth Research Foundation, PO Box 23068, 3001 KB Rotterdam, The Netherlands;6. Erasmus Medical Centre Rotterdam, Department of Psychiatry, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands;7. Erasmus Medical Centre Rotterdam, Department of Pediatric Endocrinology, PO Box 2060, 3000 CB Rotterdam, The Netherlands |
| Abstract: | Although severe motor problems in infants with Prader-Willi syndrome (PWS) are striking, motor development has never been studied longitudinally and the results of growth hormone (GH) treatment on motor development are contradictory. The authors studied whether GH treatment can enhance the effect of physical training on motor development in infants with PWS. Twenty-two infants were followed for two years during a randomized controlled trial. The treatment and control groups began GH after baseline or following a control period, respectively. Both groups followed a child-specific physical training program. Motor performance was measured every three months. Multi-level regression analysis revealed that motor development differed significantly between infants (p < .001), and this could be partially explained by baseline motor developmental level (p < .01). GH treatment enhanced the effects of child-specific physical training on both motor developmental rate and motor developmental potential. Moreover, this effect was more pronounced when GH treatment was initiated at a younger age. |
| Keywords: | Growth hormone Infants Motor development Pediatric physical therapy Physical training Prader-Willi syndrome |
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