Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia |
| |
Authors: | Kevin C Maki Andrea L Lawless Matthew S Reeves Kathleen M Kelley Mary R Dicklin Belinda H Jenks Ed Shneyvas James R Brooks |
| |
Institution: | 1. Biofortis Clinical Research, Addison, Illinois, USA;2. Pharmavite, LLC, Northridge, California, USA |
| |
Abstract: | ObjectiveThis randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a softgel capsule dietary supplement, providing esterified plant sterols/stanols 1.8 g/d, in 28 participants (~75% women) with primary hypercholesterolemia (fasting low-density lipoprotein cholesterol LDL-C] levels ≥130 and <220 mg/dL), a mean age of 58.4 y, and a mean body mass index of 27.9 kg/m2.MethodsAfter a 5-wk National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet and a single-blinded placebo lead-in, subjects received double-blinded placebo or sterol/stanol softgel capsules for 6 wk and then crossed over to the opposite product for 6 wk while continuing the TLC diet. Fasting lipids were assessed in duplicate at the end of the diet lead-in (baseline) and the end of each treatment.ResultsThe mean baseline lipid concentrations (milligrams per deciliter) were 223 for total cholesterol (TC), 179 for non–high-density lipoprotein cholesterol (non-HDL-C), 154 for low-density lipoprotein cholesterol, 44 for HDL-C, 125 for triacylglycerols, and 5.2 for TC/HDL-C. Differences from the control responses (plant sterol/stanol minus control) in the per-protocol sample were significant (P < 0.05) for LDL-C (?9.2%), non-HDL-C (?9.0%), TC (?7.4%), TC/HDL-C (?5.4%), and triacylglycerols (?9.1%). The HDL-C responses were not significantly different between treatments.ConclusionThe incorporation of softgel capsules providing esterified plant sterols/stanols 1.8 g/d into the NCEP TLC diet produced favorable changes in atherogenic lipoprotein cholesterol levels in these subjects with hypercholesterolemia. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|