Health-Related Quality of Life,Depression, and Metabolic Parameters in Overweight Insulin-Resistant Adolescents |
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| Authors: | Adrienne M. Platt Anna M. Egan Mary Jane Berquist Meredith L. Dreyer Ghufran Babar Figen Ugrasbul |
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| Affiliation: | 1. Department of Psychiatry, First Affiliated Hospital of Medical College of Xi''an Jiaotong University, Xi''an, Shaanxi, China;2. Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China;3. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan;1. Stellenbosch University, Faculty of Medicine and Health Sciences, Psychiatry, PO Box 19063, Tygerberg, Cape Town ZA 7505, South Africa;2. Departments of Developmental and Experimental Psychology, Utrecht University, Utrecht, The Netherlands;3. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town ZA 8001, South Africa;1. Pharmacology of Pain and Neuromodulation Laboratory: Preclinical Researches, Department of Pharmacology, Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;2. Animal Experimentation Unit, Graduate Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil;3. Graduate Program in Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;4. Faculty of Medicine, Health Sciences Institute, Universidade Federal do Pará, Belém, Pará, Brazil;5. Graduate Program in Biological Sciences: Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil;6. Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA, USA |
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| Abstract: | IntroductionThe purpose of this study was to examine the incidence and severity of depression and health-related quality of life (HRQoL) in youth with insulin resistance (IR) who are overweight/obese and to examine the impact on making lifestyle changes.MethodNew patients presenting for treatment in an IR clinic were screened for depression and HRQoL and reassessed twice during a 1-year treatment period. Metabolic and growth parameters were obtained for each participant.ResultsElevated symptoms of depression were reported in 51% of the sample, and these symptoms were stable over time. Approximately 10% of these youth reported moderate or severe symptoms of depression. HRQoL scores indicated a good quality of life overall with slight improvement in some areas over time. Depression scores were not associated with demographic variables or metabolic parameters.DiscussionMore than 50% of adolescents with IR and obesity reported elevated symptoms of depression. These results provide sufficient evidence for the need to conduct routine screening of depression for all youth with IR so that appropriate mental health referrals can be made. |
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