甲巯咪唑对甲状腺功能亢进症患者甲状腺激素水平及肝功能的影响研究

目的 探讨分析甲巯咪唑对甲状腺功能亢进症患者甲状腺激素水平及肝功能的影响.方法 前瞻性选择2016年1月至2019年1月在四川省林业中心医院就诊的86例甲状腺功能亢进症患者为研究对象,按随机数字表法分为研究组(n=43 )与对照组(n=43 ).其中对照组予以丙硫氧嘧啶治疗,研究组予以甲巯咪唑治疗.观察比较2组患者的临...

Effect of methimazole on thyroid hormone levels and liver function in patients with hyperthyroidism

Objective To investigate and analyze the effects of methimazole on thyroid hormone levels and liver function in patients with hyperthyroidism.Methods Eighty-six patients with hyperthyroidism who were treated in our hospital from January 2016 to January 2019 were selected as the research objects,and they were randomly divided into a study group(n=43)and a control group(n=43);the control group received for propylthiouracil treatment,the study group was treated with methimazole.The clinical efficacy,thyroid hormone[total triiodothyronine(TT3),total thyroxine(TT4),free triiodothyronine(FT3),free thyroxine(FT4),thyroxine(TSH)]levels and changes in liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBIL)],the incidence and time of liver damage were observed and compared between the two groups before and 12 months after treatment.Results The total effective rate in the study group was 95.35%,which was significantly higher than 83.72%in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the levels of thyroid hormones and liver function indexes before treatment between the two groups(P>0.05).The levels of TT3,TT4,FT3,and FT4 in the study group 12 months after treatment were(1.92±0.51)nmol/L,(120.58±10.26)nmol/L,(5.26±1.33)pmol/L,(17.35±3.84)pmol/L,respectively,which were all significantly lower than those in the control group[(2.73±0.62)nmol/L,(149.35±13.62)nmol/L,(9.25±1.89)pmol/L,(21.87±4.36)pmol/L],while TSH(2.84±0.75)nmol/L was significantly higher than the control group(2.32±0.53)nmol/L,the difference was statistically significant(P<0.05).The levels of ALT,AST,ALP,and TBIL in the study group 12 months after treatment were(45.26±7.33)U/L,(50.22±6.96)U/L,(150.34±26.34)U/L,(16.03±3.98)μmol/L,which were all significantly lower than those in the control group[(54.66±8.24)U/L,(59.64±7.15)U/L,(181.42±28.45)U/L,(21.39±4.13)μmol/L],the difference was statistically significant(P<0.05).The incidence of liver damage in the study group was 9.30%,which was significantly lower than 18.60%in the control group(P<0.05).The time of liver damage was(20.64±4.26)days,which was significantly earlier than the control group(38.25±6.39)days(P<0.05).Conclusion Compared with propylthiouracil,methimazole has a definite curative effect in the treatment of hyperthyroidism.It can effectively improve the level of thyroid hormone,and has a small effect on liver function.The incidence of liver damage is low,but liver damage occurs earlier.