MR spectroscopy features of brain in patients with mild and severe obstructive sleep apnea syndrome |
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Authors: | Alpay Alkan Resul Sharifov Muhammed Emin Akkoyunlu Rukiye Kiliçarslan Huseyin Toprak Ayse Aralasmak Levent Kart |
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Affiliation: | 1. Department of Radiology, Bezmialem Vakif University School of Medicine, ?stanbul, Turkey;2. Department of Pulmonology, Bezmialem Vakif University School of Medicine, ?stanbul, Turkey |
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Abstract: | PurposeWe investigated whether there are differences in metabolite ratios of different brain regions between mild and severe obstructive sleep apnea (OSA) patients.Materials and methodsA total of 17 mild OSA and 14 severe OSA patients were enrolled. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr and NAA/Cho ratios were calculated by using multivoxel magnetic resonance spectroscopy (MRS) (TR: 1500, TE: 135 ms) from hippocampus, putamen, insular cortex, thalamus and temporal white matter. The relationship between the two groups was evaluated with Mann–Whitney U test.ResultsNAA/Cr ratios obtained from hippocampus was found to be significantly increased in severe OSA patients compared to mild OSA patients (P= .004). Cho/Cr ratios obtained from hippocampus and putamen in severe OSA patients were significantly increased when compared to mild OSA patients (P= .003 and P= .004, respectively). In addition, NAA/Cho ratios of putamen were significantly decreased in severe OSA patients when compared to mild OSA (P= .032).ConclusionMRS identified hypoxia-related metabolite and microstructural changes in hippocampus and putamen. The metabolite changes of increase in NAA/Cr and Cho/Cr ratios and decrease in NAA/Cho ratio were more pronounced with increasing severity of OSA syndrome. |
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