支气管哮喘患儿血清25羟维生素D3水平变化及补充维生素D治疗对患儿发病、预后的影响研究

目的 探讨分析支气管哮喘患儿血清25羟维生素D3( 25 - OH - D3 )水平变化及补充维生素D治疗对患儿发病、预后的影响.方法 回顾性选择2016年1月至2019年1月承德医学院附属医院收治的200例支气管哮喘患儿为研究对象,设为A组,同时选择200例呼吸道感染的非支气管哮喘患儿、200名体检健康儿童分别设为B...

Study on the changes of serum 25-Hydroxyvitamin D3 level in children with bronchial asthma and the effect of vitamin D supplementation on the incidence and prognosis of children

Objective To investigate and analyze the changes of serum 25-hydroxyvitamin D3(25-OH-D3)levels in children with bronchial asthma and the effect of vitamin D supplementation on the onset and prognosis of children.Methods 200 children with bronchial asthma admitted to Affiliated Hospital of Chengde Medical College from January 2016 to January 2019 were selected as the research objects,and set as group A.At the same time,200 children with non-bronchial asthma with respiratory infections and 200 healthy children with physical examination were selected.Set as group B and group C;observe and compare the differences in serum 25-OH-D3 levels in groups A,B,and C;at the same time,children in group A were randomly divided into study group(n=100)and control group(n=100).The control group was given conventional treatment,and the study group was given vitamin D treatment on the basis of the control group.The changes in serum 25-OH-D3 levels before and after treatment were observed and compared between the two groups of children.The number of attacks,the severity of the disease and the number of hospitalizations.Results Serum 25-OH-D3 levels in group A,group B and group C were(20.26±3.75)μg/L,(36.98±4.26)μg/L,(37.15±4.39)μg/L,respectively.The serum 25-OH-D3 level of group A was significantly lower than that of group B and group C,the difference was statistically significant(P<0.05),while the serum 25-OH-D3 level of group B and C had no significant difference(P>0.05).Serum 25-OH-D3 levels before treatment between the study group and the control group were not significantly different[(20.07±3.48)μg/L vs.(20.39±3.78)μg/L](P>0.05);after treatment in the study group,the serum 25-OH-D3 level was(34.28±4.18)μg/L,which was significantly higher than that of the control group(24.89±3.65)μg/L,the difference was statistically significant(P<0.05).Follow-up for 1 year,the number of attacks and hospitalizations in the study group were significantly less than those in the control group[(1.01±0.23)vs.(2.23±0.54),(0.32±0.08)vs.(1.03±0.24)](P<0.05),the number of severe asthma attacks/attack was significantly lower than that of the control group[(0.28±0.06)vs.(0.41±0.11)],the difference was statistically significant(P<0.05).Conclusion The serum 25-OH-D3 level of children with bronchial asthma is significantly reduced.Vitamin D supplementation can significantly increase the serum 25-OH-D3 level of the children,reduce the number of attacks and hospitalizations,and reduce the severity of the disease.