CT引导下射频消融术治疗肝癌患者的远期疗效及对AFP、CEA水平的影响

目的研究CT引导下射频消融术治疗原发性肝癌患者的远期疗效及其对患者甲胎蛋白(AFP)和癌胚抗原(CEA)水平的影响。方法选取2016年5月至2018年10月成都医学院第二附属医院收治的100例原发性肝癌患者,随机分为试验组和对照组,每组50例,对照组采用传统肝动脉灌注化疗栓塞术治疗,试验组采用CT引导下射频消融术治疗,随访观察两组患者不同阶段的存活率和肿瘤体积变化情况,对比治疗前后两组患者的AFP和CEA水平。结果试验组患者的1年和2年生存率均明显高于对照组(88%vs.70%)、(84%vs.64%),不良反应发生率显著低于对照组(8%vs.26%),差异有统计学意义(P<0.05);两组患者经治疗后肿瘤体积均逐渐缩小,试验组治疗后不同阶段的肿瘤体积均明显小于对照组(P<0.05);两组治疗后的AFP和CEA水平均明显下降,且试验组两项指标水平明显低于对照组(P<0.05)。结论合理使用CT引导下射频消融术治疗原发性肝癌,能够显著提升远期治疗效果,促进患者AFP和CEA等肿瘤标志物水平的优化,且能够发挥微创治疗的优势,保证临床治疗的安全性。

Long-term efficacy of CT-guided radiofrequency ablation for liver cancer patients and its effect on AFP and CEA levels

Objective To study the long-term efficacy of CT-guided radiofrequency ablation in patients with primary liver cancer and its effect on patients'alpha-fetoprotein(AFP)and carcinoembryonic antigen(CEA)levels.Methods A total of 100 patients with primary liver cancer treated in the Second Affiliated Hospital of Chengdu Medical College from May 2016 to October 2018 were randomly divided into a test group and a control group,each with 50 patients.The control group was treated with traditional hepatic arterial infusion chemotherapy and embolization.In the experimental group,CT-guided radiofrequency ablation was used in the experimental group.The survival rates and tumor volume changes at different stages of the two groups were followed up.The AFP and CEA levels of the two groups were compared before and after treatment.Results The 1-year and 2-year survival rates of patients in the test group were significantly higher than those in the control group(88%vs.70%)and(84%vs.64%),and the incidence of adverse reactions was significantly lower than that in the control group(8%vs.26%).The difference was statistically significant(P<0.05);the tumor volume of the two groups of patients gradually decreased after treatment,and the tumor volume at different stages after treatment in the experimental group was significantly smaller than the control group(P<0.05);the AFP after treatment in the two groups And CEA levels decreased significantly,and the levels of the two indicators in the test group were significantly lower than those in the control group(P<0.05).Conclusions The rational use of CT-guided radiofrequency ablation for the treatment of primary liver cancer can significantly improve the long-term treatment effect,help to optimize the level of tumor markers such as AFP and CEA,and can take advantage of minimally invasive treatment to ensure Safety of clinical treatment.