Cognitive and behavioral trajectories in 22q11DS from childhood into adolescence: A prospective 6-year follow-up study |
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| Authors: | Sasja N Duijff Petra WJ Klaassen Henriëtte FN Swanenburg de Veye Frits A Beemer Gerben Sinnema Jacob AS Vorstman |
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| Institution: | 1. Department of Pediatric Psychology, Wilhelmina Children''s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands;2. Department of Medical Genetics, Wilhelmina Children''s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands;3. Department of Child and Adolescent Psychiatry and the Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands |
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| Abstract: | Patients with 22q11DS are at risk of behavioral problems and cognitive impairment. Recent studies suggest a possible intellectual decline in 22q11DS children. To date it is unknown if cognitive development is related to the behavioral problems in 22q11DS. We studied 53 children with 22q11DS who underwent cognitive and behavioral assessments at 9.5 years (T1) and 15.3 years (T2). In about one third, IQ data obtained at 7.5 years (T0) were also available. Results showed that internalizing behaviors intensified while externalizing behaviors decreased. Simultaneously, in about a third a significant decline in IQ was found, which, surprisingly, was unrelated to the behavioral changes. It can be concluded that children with 22q11DS follow a unique developmental trajectory. Cognitive deterioration is severe in some but does not appear to predict behavioral problems in early adolescence. |
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| Keywords: | 22q11-Deletion syndrome Velo-Cardio-Facial-syndrome Intelligence Behavior Longitudinal |
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