Rat brain microvessel extracellular matrix modulates the phenotype of cultured rat type 1 astroglia |
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| Authors: | J B Grinspan M Lieb J Stern M Rupnick S Williams D Pleasure |
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| Affiliation: | Third Department of Internal Medicine, Okayama University Medical School, Japan. |
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| Abstract: | Astroglia from immature rat cerebral white matter which were plated on the insoluble extracellular matrix (ECM) secreted by rat cerebral microvessel endothelial cells (RCMEC) and maintained in a defined medium were induced to become stellate and to express glutamine synthetase. These effects were not elicited by RCMEC-conditioned medium. ECM secreted by rat pleural mesothelium elicited a lesser proportion of stellate astroglia and did not induce glutamine synthetase. |
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