0.1%他扎罗汀凝胶接触治疗寻常痤疮疗效观察

目的：观察0．1％他扎罗汀凝胶短期接触治疗轻、中度面部寻常痤疮的临床疗效和安全性。方法：采用随机、平行对照的临床研究方法，入选病例外涂试验药物，每天2次，疗程12周。结果：治疗组疗后2、4、8、12周的有效率分别为24％、40％、60％、68％；对照组分别为19．2％(P=0．631)、23．1％(P=0．175)、30．8％(P=0．034)、30．8％(P=0．008)。结论：0．1％他扎罗汀凝胶短期接触治疗轻中度面部寻常痤疮疗效好，不良反应轻，有较好的耐受性。

Investigation on the Efficacy of 0.1% Tazarotene Gel in Treatment of Patients with Acne Vulgaris

Objective:To observe the clinical efficacy and safety of 0.1% tazarotene gel short-contact therapy adopted in treatment of mild or moderate facial acne. Methods:A randomized, parallel controlled clinical study was conducted. The patients were treated topically with trial drug, twice-daily (morning and evening) for 12 weeks. Results:Results showed that the effective rates were 24%,40%,60% and 68% respectively in study group at 2,4,8 and 12 weeks. In control group, the effective rates were 19.2% (P=0.631, compared to the study group), 23.1% (P=0.175), 30.8% (P=0.034) and 30.8% (P=0.008) respectively. Conclusion:Short-contact treatment of 0.1% tazarotene gel for mild to moderate facial acne was effective, safe and well tolerated.