Mixed hematopoietic chimerism and transplantation tolerance |
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Authors: | Boris Nikolic Megan Sykes |
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Institution: | (1) BMT Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA |
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Abstract: | Durable transplantation tolerance can be reliably achieved by inducing engraftment of hematopoietic cells in recipients initially
depleted of T-lymphocytes. Engraftment of donor pluripotent hematopoietic stem cells (PPHSC) produces mixed hematopoietic
chimeras in which both host and donor cells coexist and are tolerant of each other. The major mechanism of tolerance in these
chimeras is central, intrathymic clonal deletion, which is induced and maintained by immigration of both host and donor marrow-derived
cells to the host thymus, ensuring the ongoing central deletion of donorand host-reactive cells. In this article, approaches
developed in our laboratory to induce stable mixed hematopoietic chimerism and specific central deletional allogeneic and
xenogeneic tolerance without toxic or myeloablative host conditioning are reviewed. |
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Keywords: | Bone marrow chimerism Thymic transplantation Allografts Xenografts Tolerance |
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