曼性心力衰竭患者血浆B型利钠肽的变化及其监测意义

目的探讨慢性心力衰竭患者血浆B型利钠肽（BNP）的变化及其监测意义。方法选取本院心内科2010年7月。2012年7月收治的80例慢性心力衰竭患者。在患者人院前和治疗后依据NYHA心功能分级、采用ELISA法监测患者的血浆BNP水平，并行超声心动图检查，将其作为观察组，另选30名健康成人作为对照组。结果和对照组相比。观察组患者的各心功能不全血浆BNP水平明显偏高，二者差异具有高度统计学意义（P〈0．01）；和治疗前相比．治疗后观察组患者的血浆BNP水平较低，二者差异具有统计学意义（P〈0．05）；血浆BNP水平和LVEDD没有明显的相关性，而和LVEF呈负相关关系；随着心力衰竭程度越重，血浆BNP水平越高。结论慢性心力衰竭患者血浆B型利钠肽水平升高是患者早期心功能受损的敏感指标，对快速诊断和治疗慢性心力衰竭患者及迅速判断心衰严重程度有极为重要的临床价值和意义。

Changing and monitoring value of B-type natriuretic peptide in chronic congestive heart failure

Objective To investigate the changes and value of B-type natriuretic peptide （BNP） on CHF patients. Methods Eighty cases of chronic heart failure patients were selectedas the observation group patients who were admitted to our hospital cardiology from July 2010 to July 2012, regard them. Classed the Patients according to the NYHA functional, monitored the patient＇s plasma BNP levels by ELISA and parallel echocardiography before admis- sion and after treatment. Another 30 healthy adults were selected as the control group patients. Results Compared to the control group, the various heart dysfunction plasma BNP levels of the observation group patients were higher, the differences were statistically significant （P 〈 0.01）; After treatment, the level of these patients＂ plasma BNP were lower than pre-treatment, the differences were statistically significant （P 〈 0.01）. And after treatment, plasma BNP levels of the observation group were lower than pre-treatment, the differences were statistically significant （P 〈 0.05）; There was no clear correlation between plasma BNP levels and LVEDD, but plasma BNP levels and LVEF was negatively corre- lated; The level of plasma BNP was higher as the heart failure became more severe. Conclusion The rising of plasma B-type natriuretic peptide levels are sensitive indicators of early chronic heart failure impaired cardiac function of pa- tients, it has extremely important clinical value and significance in the rapid diagnosis and treatment of chronic heart failure patients, and at the same time it can quickly determine the severity of heart failure.