血必净注射液对狼疮性肾炎血管内皮细胞的保护作用

目的探讨血必净注射液对于狼疮性肾炎患者血管内皮细胞的保护作用。方法选择58例狼疮性肾炎患者。分为对照组（A组）和血必净组（B组），两组均给予激素、CTX及降压、调脂等对症处理（疗程14d）。血必净组在上述治疗基础上加用血必净50mL，加入0．9％NaCl溶液100mL静滴，每132次（疗程14d）。对所有患者治疗前后测定血浆血栓调节蛋白（TM）及尿巨噬细胞特异性趋化蛋白-1（MCP-1）浓度，并与本院门诊健康查体者20例（正常组）比较。结果入院时TM、MCP—1水平在对照组（20．4±12．1）ng／mL、（599．5＋305．3）pg／mL）]及血必净组（21．7±13．2）ng/mL、（605．2±317．2）pg／mL]均显著高于正常组（4．7±1．25）ng／ml、（138．2±42．4）pg／mL]（均P〈0．01）。血必净组患者TM、MCP—1在治疗7d（12．6±8．4）ng／mL、（408．3±108．3）pg／mLl、14d（7．5±5．27）ng／mL、（312．4±121．2）pg／mL]，明显低于对照组7d时：（16．5±10．3）ng／mL、（489±167．4）pg／mL；14d时：（10．4±4．1）ng／mL、（391．3±132．4）pg／mL）]（P〈0．05），仍高于正常组7d时：（4．4±2．1）ng／mL、（136．7±44．8）pg／mL；14d时：（4．5±1．9）ng／mL、（139．6±43．11pg／mL）（P〈0．05）。结论血必净注射液对狼疮性肾炎血管内皮具有一定的保护作用。

Protective effects of Xuebijing injection on renal endothelial cells in patients with lupus nephtitis

Objective To investigate the protective effects of Xuebijing injection on injury of renal microvascular en- dothelial cells in patients with lupus nephtitis （LN）. Methods Fifty eight LN patients were randomly divided into Xuebijing injection treatment group （group B） and control group （group A）. Both groups were treated with routine integration treatment, and additionally, patients in group B received Xuebijin injection 50 mL±0.9%NaC1 100 mL ivgtt twice a day（course of treatment 14 d）. Plasma thrombomodulin （TM） and monocyte chemoattractant protein-l（MCP-1） were both measured in all patients on the 7th and 14th day respectively after admission, and results were compared with 20 healthy volunteer （normal group）. Results TM and MCP-1 were markedly higher in control group （20.4±12.1）ng/mL, （599.5±305.3）pg/mL] and Xuebijing group （21.7±13.2）ng/mL, （605.2±317.2） pg/mL] than those of healthy volunteers （4.7±1.25） ng/mL, （138.2±42.4） pg/mL] before the treatment（all P 〈 0.01）. After treatment, TM and MCP-1 in Xuebijing group7 d： （12.6±8.4）ng/mL, （408.3±108.3） pg/mL; 14 d： （7.5±5.27） ng/mL, （312.4±121.2） pg/mL] were markedly lower than control group7 d： （16.5±10.3） ng/mL, （489±167.4） pg/mL; 14 d：（10.4±4.1） ng/mL, （391.3±132.4） pg/mL], but still higher than those of healthy volunteers 7 d： （4.4±2.1） ng/mL, （136.7-±44.8） pg/mL; 14 d （4.5±1.9） ng/mL, （139.6±43.1） pg/mL] （all P 〈 0.05）. Conclusion Xuebijing injection can protect the endothelial in LN patients.