EBV—DNA定量检测对鼻咽癌的诊断 |
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引用本文: | 李哲,翁玉玲.EBV—DNA定量检测对鼻咽癌的诊断[J].中国当代医药,2013(14):106-107. |
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作者姓名: | 李哲 翁玉玲 |
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作者单位: | [1]广东省东莞市大朗医院输血科,广东东莞523770 [2]广东省东莞市人民医院检验科,广东东莞523000 |
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摘 要: | 目的通过对鼻咽癌患者经治疗后EBV—DNA含量变化的观察,为临床诊治陔病寻求最佳方法。方法血浆EBV—DNA检测采用荧光定量PCR法,选择确诊的145例鼻咽癌患者为研究对象,对其EBV-DNA进行定量检测,并以同期健康者140名的血浆情况进行对比研究。结果鼻咽癌组中有136例(93.79%)患者血浆EBV—DNA呈阳性:健康组中有10例(7.14%)血浆EBV—DNA呈阳性,鼻咽癌组患者出浆EBV—DNA阳性检出率明显高出健康组(P〈0.01);血浆EBV-DNA呈阳性的患者在治疗过程中,血浆EBY—DNA含量呈逐渐下降趋势。结论给予鼻咽癌患者EBV—DNA定量检测,对诊断和指导治疗价值明显。
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关 键 词: | EBV—DN 定量检测 鼻咽癌 诊断 |
Quantitative detection of EBV-DNA for diagnosis of nasopharyngeal carcinoma |
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Institution: | LI Zhe, WONG Yuling( 1. Department of Blood Transfusion, Dalang Hospital of Dongguan City in Guangdong Province, Dongguan 523700, China; 2.Department of Clinical Laboratory, People's Hospital of Dongguan City in Guangdong Province, Dongguan 523000, China ) |
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Abstract: | Objective To seek the best approach of diagnosis and treatment for the disease through observing the changes of EBV-DNA content of nasopharyngeal carcinoma patients after treatment. Methods The plasma EBV-DNA was detected by fluorescence quantitative PCR method. One hundred and forty five patients confirmed as nasopharyngeal carcinoma were selected as study object. Their plasma EBV-DNA were detected and compared with those of 140 healthy persons in corresponding time. Results In the nasopharyngeal carcinoma group, 136 cases (93.79%) showed plasma EBV-DNA-positive, while 10 cases (7.14%) in healthy group. The plasma EBV-DNA-positive detection rate of nasopharyngeal carcinoma group was significantly higher than that of healthy group (P 〈 0.01). In plasma EBV-DNA- positive patients, the plasma EBV-DNA content decreased gradually in the course of treatment. Conclusion The quantitative detection of EBV-DNA for nasopharyngeal carcinoma patients has significant value in diagnosing and guiding treatment of the disease. |
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Keywords: | EBV-DN Quantitative detection Nasopharyngeal carcinoma Diagnosis |
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