胎儿纤维连接蛋白联合宫颈长度检测在早产预测中的临床应用

目的研究胎儿纤维连接蛋白（fetal fibronentin，fFN）及宫颈长度的检测在早产预测中的临床应用。方法用fFN快速测试条对有先兆早产症状的孕妇进行阴道后穹隆分泌物中fFN的检测及经会阴超声检测宫颈长度，结合孕妇的妊娠结局进行分析。结果两种方法联合预测早产的敏感性、特异性、阳性预测值、阴性预测值分别为93.3％、46．7％、63．6％、87．5％。结论先兆早产孕妇阴道分泌物fFN检测是预测早产较为可靠的指标。

Clinical application of detection of fetal protein fiber connections with the cervical length in prediction of premature

Objective To investigate the clinical application of fetal fibronectin protein （fFN） and cervical length monitoring in prediction for preterm delivery. Methods For pregnant women who had symptoms of threatened preterm labor, the fFN in posterior fornix secretions was tested by rapid fFN test strip, and the cervical length was measured by transperineal ultrasound. The results combined with pregnancy outcomes of these pregnant women were analyzed. Resuits The sensitivity, specificity, positive predictive value, and negative predictive value of jointly applying the two methods for predicting preterm delivery were 93.3%, 46.7%, 63.6%, and 87.5%, respectively. Conclusion For pregnant women with threatened preterm labor, fFN test of vaginal secretions is a more reliable indicator for predicting premature labor. The fFN test combined with detection of cervical length can improve the predicting accuracy of preterm delivery.