| 晚期卵巢癌患者外周血与腹腔积液中ERCC1基因表达研究 |
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| 引用本文： | 张自森,李灿宇,巴楠,张红巧,王利娟,吴敏.晚期卵巢癌患者外周血与腹腔积液中ERCC1基因表达研究[J].中国妇幼保健,2013,28(20). |
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| 作者姓名： | 张自森 李灿宇 巴楠 张红巧 王利娟 吴敏 |
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| 作者单位： | 1. 郑州大学第五附属医院 河南郑州450052
2. 郑州大学第三附属医院 |
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| 基金项目： | 郑州市科技发展计划项目 |
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| 摘 要： | 目的:探讨晚期卵巢癌患者外周血与腹腔积液中ERCC1基因表达水平及其临床意义。方法:RT-PCR检测36例晚期卵巢癌患者化疗前外周血与腹腔积液中ERCC1 mRNA表达水平,分析其与腹腔热灌注顺铂治疗疗效的关系。结果:外周血ERCC1 mRNA表达水平显著高于腹腔积液中的表达,两者呈显著正相关(P<0.05)。腹腔积液中ERCC1 mRNA表达水平与热灌注顺铂疗效显著相关,有效组呈低水平表达。外周血ERCC1 mRNA表达与热灌注顺铂疗效无关(P>0.05)。结论:腹腔积液中ER-CC1 mRNA有助于晚期卵巢癌患者腹腔热灌注顺铂疗效预测。
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| 关 键 词： | 卵巢癌 腹腔热灌注化疗 腹腔积液 ERCC1 基因表达 |
Expression of ERCC1 gene in peripheral blood and ascites of advanced ovarian carcinoma |
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| Abstract: | Objective:To investigate the expression of ERCC1 mRNA in peripheral blood and ascites of advanced ovarian carcinoma.Methods:Peripheral blood and ascites samples were collected from 36 cases of advanced ovarian carcinoma treated by intraperitoneal hyperthermic perfusion chemotherapy with cisplatin.The expressions of ERCC1 mRNA in peripheral blood and ascites were detected by RT-PCR.The relationship of gene expression with clinical characteristics and chemotherapy response was analyzed.Results:The expression of ERCC1 mRNA in peripheral blood was significantly higher than that in ascites,with a significant correlation between them.The expression of ERCC1 mRNA in ascites correlated with chemotherapy response with a significant difference,while no significant correlation was observed in peripheral blood.The effective group had low expression of ERCC1 mRNA in ascites.Conclusion:The expression of ERCC1 mRNA in ascites may contribute to predict the efficacy of advanced ovarian carcinoma treated by intraperitoneal hyperthermic perfusion chemotherapy with cisplatin. |
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| Keywords: | Ovarian carcinoma Intraperitoneal hyperthermic perfusion chemotherapy Ascites ERCC1 Gene expression |
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