血清CRP、cTnI联合检测在急性心肌梗死诊断中的应用

目的探讨血清超敏C-反应蛋h（hs—CRP）、肌钙蛋白I（cTnI）及肌酸激酶同T酶（CK—MB）联合检测在急性心肌梗死（AMI）诊断中的临床价值。方法对38例心肌梗死胸骨后疼痛发作2～6h的患者及48例心肌梗死胸骨后疼痛发作12～24h的患者采用免疫散射比浊定量法检测其血清CPR．采用免疫抑制法检测CK—MB．采用免疫荧光法检测其血清cTnI，并与39例正常对照组进行比较。结果两AMI组患者的CRP、cTnI及CK—MB浓度较正常对照组高；联合检测CRP＋CK—MB、CRP＋cTnI＋CK—MB、cTnI＋CRP阳性检出率均为100．0％．结论联合检测hs-CRP、cTnI在AMI早期诊断中有很高的特异性及灵敏度，可作为AMI的预后临测及疗效观察的指标。

Clinical calue of measuring serum level of high sensitivity C-reactive protein and cardiac troponin I for acute myocardial infarction in early stage

Objective To investigate the value of measuring serum level of hs-CRP, CK-MB and cTnl in patient, s with acute myocardial infarction in early stage. Methods The serum levels of hs-CRP, CK-MB and eTnI were measured in 38 patients with AMI in 2-6 hours after the onset of symptoms and 48 cases in 12-24 ilours after the onset of symptoms and 39 healthy people respectively. The serum CPR was detected by immune scattering turbidimetric quantitative method, CK-MB was detected by immunosuppression, cTnI was detected by innnunofluorescenee assay. The resuhs were compared with 39 cases of control group. Results In patients with AMI, cTnI, CK-MB and CRP were significantly higher than healthy individuals. CRP positive rate of combined deteetion of CRP＋CK-MB, CRP＋cTnI＋CK-MB, cTnI＋CRP were all 100.0%. Conclusion The combined detection of serum hs-CRP and cTnl has high specifieity and sensitivity in early diagnosis of AMI, can be used as the prognosis monitoring and curative effect observation index of AMI.