米非司酮治疗围绝经期功能性子宫出血临床观察 |
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引用本文: | 常静,龚坤英.米非司酮治疗围绝经期功能性子宫出血临床观察[J].中国当代医药,2013(15):31-32. |
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作者姓名: | 常静 龚坤英 |
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作者单位: | [1]河南省周口市妇幼保健院妇产科,河南周口466000 [2]河南省周口市中心医院妇产科,河南周口466000 |
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摘 要: | 目的 探讨米非司酮治疗围绝经期功能性子宫出血的临床疗效.方法将84例围绝经期功能性子宫出血患者分为对照组和观察组各42例,对照组给予安宫黄体酮10 mg/d治疗,观察组采用米非司酮6.25 mg/d治疗,观察两组治疗后疗效.结果 两治疗后FSH、E2、LH和P水平均较治疗前有明显下降,且观察组下降幅度较对照组更为明显(P < 0.05);观察组子宫前、后径及子宫内膜厚度、子宫体积改善均显著优于对照组(P < 0.05);对照组不良反应发生率为19.05%,观察组为4.76%,两组不良反应发生率比较差异有统计学意义(P < 0.05).结论 米非司酮治疗围绝经期功能性子宫出血临床疗效可靠,且不良反应较轻,值得推广应用.
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关 键 词: | 米非司酮 功能性子宫出血 围绝经期 临床观察 |
A Clinical observation of mifepristone for treatment of perimenopausal dysfunctional uterine bleeding |
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Authors: | CHANG Jing GONG Kunying |
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Institution: | 1.Department of Gynecology of Maternity and Child Health Care Hospital of Zhoukou Ciry, He'nan Province, Zhoukou 466000, China; 2.Department of Obstetrics and Gynecology, the Center Hospital of Zhoukou City, He'nan Province, Zhoukou 466000, China |
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Abstract: | Objective To explore the clinical effect of mifepristone for treatment of perimenopausal dysfunctional uterine bleeding. Methods Eighty-four patients of perimenopausal dysfunctional uterine bleeding were randomly divided into control group and observation group,with each groups of 42 patients, the control group were treated with 10 mg/d Medroxyprogesterone Acetate, the observation group were treated with 6.25 mg/d Mifepristone, follow up 3 months and evaluate the clinical efficacy of two groups. Results After treatment, the FSH,E2,LH and P level of two groups signif- icantly decreased (P 〈 0.05), and the observation group lower than control group (P 〈 0.05); The improvement of en- dometrial thickness and uterus volume in observation group were significantly decreased than control group (P 〈 0.05); The rate of adverse of control group was 19.05%, and observation group was 4.76%, there was significantly difference between two groups (P 〈 0.05). Conclusion Treatment of perimenopausal dysfunctional uterine bleeding with mifepris- tone is a safe and validity method, is worthy of promotion and application. |
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Keywords: | Mifepristone Perimenopausal Dysfunctional uterine bleeding Clinical observation |
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