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| 锌金属硫蛋白拮抗甲基汞对红细胞膜损伤的作用 | |
| 引用本文： | 徐乐焱,王毅,邱炳源,王振. 锌金属硫蛋白拮抗甲基汞对红细胞膜损伤的作用[J]. 卫生研究, 2000, 29(2): 80-82 |
| 作者姓名： | 徐乐焱 王毅 邱炳源 王振 |
| 作者单位： | 1. 中国医学科学院中国协和医科大学北京协和医院核医学科,北京,100730 2. 白求恩医科大学预防医学院 3. 秦皇岛市卫生防疫站 |
| 摘 要： | 为了探讨锌金属硫蛋白拮抗ＭｅＨｇ对细胞膜的损伤作用及其机理，为预防甲基汞中毒提供科学依据，研究了不同剂量的锌诱导产生的ＺｎＭＴ对ＭｅＨｇ染毒小鼠红细胞膜构象，膜巯基含量，膜流动性和通透性等的影响，实验结果表明；不同剂量的Ｚｎ可以诱导小鼠肝脏产生ＺｎＭＴ，随着实验组Ｚｎ剂量的增加，肝脏内ＺｎＭＴ的含量也相应的增加，呈剂量－效应关系。 |
| 关 键 词： | 甲基汞 锌金属硫蛋白 膜通透性 红细胞膜损伤 |
| 修稿时间： | 1999-11-08 |
The protective effects of zinc metallothionein against erythrocyte membrane damage induced by methylmercury |
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| Xu Leya,Wang Yi,Qiu Bingyuan,Wang Zhen. The protective effects of zinc metallothionein against erythrocyte membrane damage induced by methylmercury[J]. Journal of hygiene research, 2000, 29(2): 80-82 | |
| Authors: | Xu Leya Wang Yi Qiu Bingyuan Wang Zhen |
| Affiliation: | Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. |
| Abstract: | The influences of zinc metallothionein(ZnMT) induced by Zn on mice erythrocyte membrane configuration, membrane sulfhydryl content, membrane fluidity, membrane permeability and so on after methylmercury (MeHg) treatment were studied, the protection of ZnMT against the membrane damage of MeHg was studied. The results showed that Zn could induce the production of ZnMT in the liver of mice. With the increase of Zn content, the level of ZnMT increased and had dose-effect relationship between them (r = 0.996). ZnMT could protect membrane configuration and -SH and prevent the damage of MeHg on the membrane fluidity and permeability. The results also showed that the dose of Zn administered to mice should be appropriate. High doses of Zn could cause damages. |
| Keywords: | methgl mercury zinc metallothionein sulfhydryl membrane fluidity membrane permeability |
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