强迫症患者静息态脑功能局部一致性研究

目的 通过静息态功能磁共振研究未用药强迫症患者基础状态下的自发脑活动特征,探讨强迫症静息状态下的脑神经功能改变.方法 采用功能磁共振成像技术(fMRI),检测静息状态下14例未用药强迫症患者(病例组)、以及14例性别、年龄、受教育程度与患者相匹配的对照(对照组)的自发脑功能活动,并对两组分别进行两比较.利用REST软件分析fMRI数据,计算其全脑Reho值,用SPM2软件进行两样本t检验(P＜0.0002).结果 与对照组相比,病例组在右额叶、右侧顶叶、右侧岛叶、左侧扣带回、左侧顶叶局部一致性显著增强(P＜0.0002,未校正;k≥10).结论 强迫症静息状态下局部脑区存在较高的神经元活动一致性,这些脑区可能在强迫症的发病机制发挥了重要的作用.

Regional homogeneity in the patients with obsessive-compulsive disorder:a resting-state functional magnetic resonance imaging study

Objective To explore differences of brain spontaneous activity in resting state between obsessive-compulsive disorder(OCD)and control using function magnetic resonance imaging(fMRI)in order to find the base of neural activity in OCD associated with phathophysiological mechanism.Methods 14 subjects with OCD and 14 sex,age and education-matched controls underwent fMRI scans while resting state.ReHo analyses were used to detect neural spontaneous activity across the whole brain by REST.Two within-group analysis was performed between cases and controls by t-test(P＜0.0002)by SPM5.Results Compared with normal controls,the ReHo of right frontal cortex,right parietal cortex,right insula,left cingulated and left parietal cortex were significantly increased in resting state in OCD(P＜0.0002,unadjusted;k≥10).Conclusion The present result impliate that these regions play importance role in mechanism of pathophysioiogy in OCD.