雷公藤多甙对格林-巴利综合征患者白细胞介素6的影响

目的：探讨白细胞介素６（ＩＬ－６）在格林－巴利综合征（ＧＢＳ）发病中的作用以及免疫抑制性药（雷公藤多甙）对其的影响。方法：按Ａｓｂｕｒｙ标准选择ＧＢＳ患者４３例，以分层随机原则为２组，分别用肾上腺皮质类固醇（对照组）和雷公藤多甙（治疗组）治疗，并取静脉血和脑脊液配对标本２ｍｌ，用双抗体夹心ＥＬＩＳＡ法测定ＩＬ－６。结果：（１）治疗前ＧＢＳ患者血清、脑脊液中ＩＬ－６测定水平明显高于正常值；（２）治疗

Effect of Tripterygium Polyglycoside on Interleukin-6 in Patients with Guillain-Barre Syndrome

To study the action of interleukin-6(IL-6) in pathogenesis and effect of patients with GuillainBarre syndrome (GBS). Methods: Forty-three patients of GBS were selected according to Asbury's standard and divided into two groups on layer randomize principle, they were treated with adrena1 corticosteroid and Tripterygium polyglycoside (TP) respectively. Serum and cerebrospinal fluid (CSF) content of IL-6 were measured by double antibody sandwich ELISA method. Results: (1)The serum and CSF content of IL-6 in GBS group was higher than those in the normal control group significantly; (2) There was Positive correlation between CSF IL-6 and clinical severity (P <0.01 ) before treatment; (3)After treatment the clinical symptoms were improved in both groups, but the TP treated group showed better effect than the control group in improv ing symptoms and lowering serum IL-6 level (P <0.05). Conclusion: CSF level of IL-6 could be taken as one of the criteria for severity evaluation of patient's condition. TP is superior in suppressing abnormal immune reaction to adrenal corticosteroid in GBS patients.