妊娠期肺损伤机制与功能保护

机体遭受严重的感染、创伤、休克、手术打击以及再灌注损伤等均可导致急性肺损伤(acute lung injury,ALI)发生。ALI治疗困难;急性呼吸窘迫综合征(ARDS)病死率高。产后失血性休克、肺部感染、大量输血输液、羊水栓塞导致弥漫性血管内凝血、宫内感染、重度子痫前期等是导致ALI及ARDS的常见病因。因此,妊娠期应严密监测肺功能及母儿状况,预防并及早发现ALI的诱发因素,及时治疗。

Mechanisms of pregnancy induced lung injury and lung functional protection

Acute lung injury(ALI)happened when the body suffered a severe infection,trauma,shock,surgical strike or reperfusion injury,et.It’s difficult to cure ALI,and meanwhile the mortality of acute respiratory distress syndrome(ARDS)is high.Postpartum uncontrolled hemorrhagic shock,pulmonary infection,numerous transfusions infusion,amniotic fluid embolism leading to DIC,intrauterine infection and severe preeclampsia pregnancy are common causes of ALI and ARDS.It should be closely monitored the lung function and the status of mother and fetal in pregnancy,prevent and early detect the causative factors of ALI,and give timely treatment.