自主神经系统在心房颤动中的作用和联系

心房颤动（房颤）在临床上极为常见,目前心房颤动的机制尚未阐明,其中自主神经系统在房颤的发生、维持、终止和决定室性心律上是一个潜在的强大的调节因素。存在于中枢、神经节、外周组织、细胞和亚细胞水平的交感和副交感系统的复杂相互作用都能够改变心脏的传导性和不应期,较为重要的是分布于心脏的自主神经的调节作用能引起心房节律的改变以及影响触发活动的产生和类型,所有这些变化都能引发和维持房颤。本文就心脏自主神经系统在房颤发生发展过程中的可能的作用机制及相互联系作一综述,为基础研究和临床实践中对房颤的机制研究和治疗提供参考依据和理论基础。

Interrelationships between the Autonomic Nervous System and Atrial Fibrillation

Atrial fibrillation is common in clinic.Mechanisms responsible for atrial fibrillation are not completely understood ,among various mechanisms, the autonomic nervous system is a potentially potent modulator of the initiation, maintenance, termination and ventricular rate determination of atrial fibrillation. Complex interactions exist between the parasympathetic and sympathetic nervous systems on the central, ganglionic, peripheral, tissue, cellular and subcellular levels that could be responsible for alterations in conduction and refractoriness properties of the heart ,the more important is that autonomic nervous which distribute in heart may change arythmia and influnte the presence and type of triggeredactivity, all of which could arouse and maintain atrial fibrillation. this artical reviews the roles and interrelationship of automomic nerve system in atrial fibrillation.